Where do they come from and where do they go: candidates for regulating extracellular vesicle formation in fungi

In the past few years, extracellular vesicles (EVs) from at least eight fungal species were characterized. EV proteome in four fungal species indicated putative biogenesis pathways and suggested interesting similarities with mammalian exosomes. Moreover, as observed for mammalian exosomes, fungal EV...

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Published inInternational Journal of Molecular Sciences Vol. 14; no. 5; pp. 9581 - 9603
Main Authors Oliveira, Débora L, Rizzo, Juliana, Joffe, Luna S, Godinho, Rodrigo M C, Rodrigues, Marcio L
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 02.05.2013
Molecular Diversity Preservation International (MDPI)
Subjects
Biological Transport
exosomes
Exosomes - metabolism
extracellular vesicle biogenesis
flippases
fungal extracellular vesicles
Fungal Proteins - metabolism
Fungi - metabolism
GRASP
Models, Biological
Review
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Summary:In the past few years, extracellular vesicles (EVs) from at least eight fungal species were characterized. EV proteome in four fungal species indicated putative biogenesis pathways and suggested interesting similarities with mammalian exosomes. Moreover, as observed for mammalian exosomes, fungal EVs were demonstrated to be immunologically active. Here we review the seminal and most recent findings related to the production of EVs by fungi. Based on the current literature about secretion of fungal molecules and biogenesis of EVs in eukaryotes, we focus our discussion on a list of cellular proteins with the potential to regulate vesicle biogenesis in the fungi.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms14059581