Deep Eutectic Solvents and Multicomponent Reactions: Two Convergent Items to Green Chemistry Strategies

• Published in: ChemistryOpen (Weinheim) Vol. 10; no. 8; pp. 815 - 829
• Main Authors: Calvo‐Flores, Francisco G., Mingorance‐Sánchez, Cristina
• Format: Journal Article
• Language: English
• Published: Weinheim John Wiley & Sons, Inc 01.08.2021; John Wiley and Sons Inc; Wiley-VCH
• Subjects: alternative solvents; biocompatible solvents; Biodegradability; By products; Chemical reactions; Chemical synthesis; Chloride; deep eutectic solvents; Efficiency; Environmental impact; Eutectic reactions; Green chemistry; Hydrogen bonds; Ionic liquids; Laboratories; Minireview; Minireviews; Solvents; State-of-the-art reviews; sustainability; Sustainable development; Thermal stability; Viscosity; Volatility
• ISSN: 2191-1363; 2191-1363
• DOI: 10.1002/open.202100137

One of the highlights of green chemistry is the development of techniques and procedures with low environmental impact. In the last years, deep eutectic solvents (DES) have become an important alternative to conventional organic solvents. For a period ionic liquids have provoked remarkable interest, but they have been displaced by DES because they show easier preparation methods, lower prices, many of them are biodegradable and compatible with biological systems. In addition, they show adjustable physicochemical properties, high thermal stability, low volatility and are compatible with water. In this paper is reviewed the state of the art of the use of DES paying special attention to the role of reaction media in organic synthesis. Deep eutectic solvents are an interesting alternative to conventional solvents, both as a reaction medium and for many processes and technologies used in chemistry and related sciences. They are easily prepared, versatile, many of them can be obtained from renewable sources and can be designed and adapted for specific processes. For all these reasons, they have been studied intensively in recent years and their interest is constantly growing. This paper reviews some of the most prominent applications and which are the fields of interest that may be a focus of applications in the near future.