Fucoidan inhibits the development of proteinuria in active Heymann nephritis

• Published in: Phytotherapy research Vol. 19; no. 1; pp. 50 - 53
• Main Authors: Zhang, Q, Li, N, Zhao, T, Qi, H, Xu, Z, Li, Z
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 2005; Wiley
• Subjects: Administration, Oral; algae and seaweeds; Animals; Biological and medical sciences; Chinese traditional medicine; Dose-Response Relationship, Drug; fucoidan; General pharmacology; Glomerulonephritis - complications; Glomerulonephritis - drug therapy; Glomerulonephritis - immunology; Heymann nephritis; Heymann Nephritis Antigenic Complex - immunology; Kidney Tubules - drug effects; Kidney Tubules - immunology; Laminaria; Laminaria japonica; Laminariales; Medical sciences; nephritis; Oriental traditional medicine; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; polysaccharides; Polysaccharides - administration & dosage; Polysaccharides - pharmacology; Polysaccharides - therapeutic use; proteinuria; Proteinuria - etiology; Proteinuria - immunology; Rats; Rats, Wistar; urinary tract diseases; Glomerulonephritis; Kidney disease; Animal model; Urinary system disease; Laminaria japonica; Laminariales; Heymann nephritis; Rat; Pharmacognosy; Algae; Rodentia; fucoidan; Medicinal plant; Heterokontophyta; Vertebrata; Mammalia; Laminaria; Plant origin; Phaeophyceae; Thallophyta; Proteinuria
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.1623

Fucoidan, the sulphated polysaccharide extracted from brown seaweed, has various biological activities. The effect of fucoidan on the formation of proteinuria and renal functions in active Heymann nephritis was investigated in this study. Active Heymann nephritis was induced by administering brush border protein of rat proximal uriniferous tubules (FX1A). Fucoidan was administered by oral intubation to Heymann nephritis rats at three doses (50, 100 and 200 mg[sol ]kg) once daily for 4 weeks. The elevated urinary protein excretion and plasma creatinine due to the induction of Heymann nephritis were significantly reduced by fucoidan at doses of 100 and 200 mg[sol ]kg. The results indicated that fucoidan has a renoprotective effect on active Heymann nephritis and is a promising therapeutic agent for nephritis. Copyright © 2005 John Wiley & Sons, Ltd.