Current detection technologies for circulating tumor cells

Circulating tumor cells (CTCs) are cancer cells that circulate in the blood stream after being naturally shed from original or metastatic tumors, and can lead to a new fatal metastasis. CTCs have become a hotspot research field during the last decade. Detection of CTCs, as a liquid biopsy of tumors,...

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Bibliographic Details
Published inChemical Society reviews Vol. 46; no. 8; pp. 2038 - 2056
Main Authors Shen, Zheyu, Wu, Aiguo, Chen, Xiaoyuan
Format Journal Article
LanguageEnglish
Published England 18.04.2017
Subjects
Animals
antineoplastic agents
biopsy
Blood
Blood Circulation
blood flow
Cancer
cancer recurrence
Classification
drug therapy
early diagnosis
Effectiveness
Fatal
Hot spots
Humans
Lignans
Limit of Detection
Liquids
metastasis
Nanostructures - chemistry
neoplasm cells
neoplasms
Neoplasms - diagnosis
Neoplasms - metabolism
Neoplastic Cells, Circulating
Optical Imaging - methods
Particle Size
Spectrum Analysis - methods
Surface Properties
Tumors
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Summary:Circulating tumor cells (CTCs) are cancer cells that circulate in the blood stream after being naturally shed from original or metastatic tumors, and can lead to a new fatal metastasis. CTCs have become a hotspot research field during the last decade. Detection of CTCs, as a liquid biopsy of tumors, can be used for early diagnosis of cancers, earlier evaluation of cancer recurrence and chemotherapeutic efficacy, and choice of individual sensitive anti-cancer drugs. Therefore, CTC detection is a crucial tool to fight against cancer. Herein, we classify the currently reported CTC detection technologies, introduce some representative samples for each technology, conclude the advantages and limitations, and give a future perspective including the challenges and opportunities of CTC detection.
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ISSN:0306-0012
1460-4744
1460-4744
DOI:10.1039/C6CS00803H