Near-infrared fluorescence lymphatic imaging of Klippel-Trénaunay syndrome

• Published in: Journal of vascular surgery. Venous and lymphatic disorders (New York, NY) Vol. 5; no. 4; pp. 533 - 537
• Main Authors: Rasmussen, John C., PhD, Zvavanjanja, Rodrick C., MD, MSc, FRCR, Aldrich, Melissa B., PhD, Greives, Matthew R., PhD, Sevick-Muraca, Eva M., PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2017
• Subjects: Adult; Coloring Agents - administration & dosage; Diagnosis, Differential; Edema - diagnostic imaging; Humans; Hypertrophy - diagnostic imaging; Indocyanine Green - administration & dosage; Klippel-Trenaunay-Weber Syndrome - diagnostic imaging; Lower Extremity - diagnostic imaging; Lymphatic Vessels - abnormalities; Lymphatic Vessels - diagnostic imaging; Male; Optical Imaging - methods; Port-Wine Stain - diagnostic imaging; Predictive Value of Tests; Risk Factors; Sensitivity and Specificity; Surgery
• ISSN: 2213-333X; 2213-3348
• DOI: 10.1016/j.jvsv.2017.01.011

Abstract The relationship between lymphatic and venous malformations in Klippel-Trénaunay syndrome is difficult to assess. Herein the authors describe near-infrared fluorescence lymphatic imaging to assess the lymphatics of a subject with a large port-wine stain and right leg edema. Although lymphatic vessels in the medial, affected knee appeared dilated and perhaps tortuous, no definitive abnormal lymphatic pooling or propulsion was observed. The lymphatics in the affected limb were well defined but less numerous than in the contralateral limb, and active, contractile function was observed in all vessels. As demonstrated, near-infrared fluorescence lymphatic imaging enables the clinical assessment of lymphatics in lymphovenous malformations.