Iron acquisition pathways and colonization of the inflamed intestine by Salmonella enterica serovar Typhimurium

• Published in: International journal of medical microbiology Vol. 306; no. 8; pp. 604 - 610
• Main Authors: Costa, Luciana F, Mol, Juliana P.S, Silva, Ana Patricia C, Macêdo, Auricélio A, Silva, Teane M.A, Alves, Geraldo E.S, Winter, Sebastian, Winter, Maria G, Velazquez, Eric M, Byndloss, Mariana X, Bäumler, Andreas J, Tsolis, Renée M, Paixão, Tatiane A, Santos, Renato L
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.12.2016
• Subjects: Animal models; Animals; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Cattle; Disease Models, Animal; Fe2; Fe3; Female; Gastroenteritis - microbiology; Infectious Disease; Inflammation; Intestines - microbiology; Iron - metabolism; Male; Medical Education; Metabolic Networks and Pathways - genetics; Mice, Inbred C57BL; Salmonella; Salmonella Infections - microbiology; Salmonella typhimurium - metabolism; Virulence Factors - genetics; Virulence Factors - metabolism; Fe 2; Salmonella; Animal models; Inflammation; Fe 3; Fe2; Fe3; Fe(2+); Fe(3+)
• ISSN: 1438-4221; 1618-0607
• DOI: 10.1016/j.ijmm.2016.10.004

Highlights • Ferric iron uptake via IroN and TonB uptake contributes to fitness of Salmonella typhimurium in the inflamed intestine. • Ferrous iron uptake via FeoB contributes to Salmonella fitness in the intestine after antibiotic treatment. • The benefit conferred by FeoB after antibiotic treatment is independent of T3SS-induced intestinal inflammation. • Disruption of the gut microbiota by antibiotics may alter the availability of ferrous iron to colonizing Salmonella.