Effect of brown adipose tissue/cells on the growth of mouse hepatocellular carcinoma in vitro and in vivo

• Published in: Oncology letters Vol. 17; no. 3; pp. 3203 - 3210
• Main Authors: Liu, Dong, Li, Yi, Shang, Yue, Wang, Wendie, Chen, Shu-Zhen
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.03.2019; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Abdomen; Adipose tissue; Body fat; Cancer; Carcinoma; Care and treatment; Development and progression; Experiments; Gene expression; Health aspects; Hepatocellular carcinoma; Immunotherapy; Lipoproteins; Liver; Liver cancer; Metabolic disorders; Obesity; Oncology; Physiological aspects; Sorafenib; Surgery; Triglycerides; Tumors; Beijing China; China; H22 cell viability; brown adipose tissue excision; hepatocellular carcinoma; brown adipose tissues
• ISSN: 1792-1074; 1792-1082
• DOI: 10.3892/ol.2019.9977

Activation of brown adipose tissue (BAT) is an effective strategy for treating obesity. Hepatocellular carcinoma (HCC) is a life-threatening hepatic malignancy with a high mortality rate. Considering that obesity is a risk factor for HCC, the aim of the present study was to investigate the association between HCC and BAT. Using a mouse model, H22 transplantation led to an increase in liver weight, a decrease in the weight of BAT and white adipose tissue, and an increase in the serum level of triacylglycerol (TG). In the BAT excision model, the removal of BAT led to increased growth of H22 tumors, which was accompanied by a more marked increase in liver weight and in the serum level of TG. The and intervention models with primary brown adipose cells (BACs) indicated that primary BACs can directly decrease the viability of H22 cells and the growth of tumors. In conclusion, BAT is a protective organ or tissue against HCC, and BACs may be a potential therapeutic tool for the treatment of HCC.