Synthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime

• Published in: Heliyon Vol. 8; no. 11; p. e11332
• Main Authors: Mahmood, Waqas, Ahmad, Irshad, Khan, Mohsin Abbas, Ali Shah, Syed Adnan, Ashraf, Muhammad, Shahzad, Mirza Imran, Pervaiz, Irfan, Sajid-ur-Rehman, Muhammad, Khurshid, Umair
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.11.2022; Elsevier
• Subjects: Antiviral; Cefpodoxime; Corona virus class; FTIR; NMR (1H and 13C); Schiff bases; NMR (1H and 13C); Schiff bases; Antiviral; FTIR; Cefpodoxime; Corona virus class
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2022.e11332

Synthesis of new Cefpodoxime derivatives via Schiff Bases mechanism and the efficiency of their antimicrobial and antiviral activities were addressed. They were analyzed for structural validation by using spectroscopic techniques using FTIR, 1HNMR, and 13CNMR. Molecular docking against IBV Virus papain-like protease (PLPro) was done with Auto dock tools against compounds having excellent IC50 values against IBV (Corona Class) virus. All derivatives showed strong zone of inhibition ranges from (55 ± 2.0 to 70 ± 0.8 mm) against E. coli. Compounds 1,2,4 and 6 derivatives showed remarkable activity against Stenotrophomonas maltophilia and Serratia marcescens. But For most the newly synthesized derivatives C1 (64 ± 1.60), C3 (32 ± 0.80), and C8 (64 ± 1.60) showed potential IC50 values against two variants of Corona class viruses i.e. Avian Influenza (H9) and Avian corona (IBV) viruses. The current study revealed that newly synthesized Schiff Bases possessed strong anti-viral potential. Further studies may make a breakthrough in medical sciences to tackle latest challenges such as Corona Virus Diseases. Cefpodoxime; Corona virus class; Antiviral; Schiff bases; FTIR; NMR (1H and 13C).