Complications of chest wall around malignant tumors: differences based on reconstruction strategy

• Published in: BMC cancer Vol. 24; no. 1; pp. 964 - 13
• Main Authors: Asanuma, Kunihiro, Tsujii, Masaya, Hagi, Tomohito, Nakamura, Tomoki, Kataoka, Takeshi, Uchiyama, Teruya, Adachi, Ryohei, Sudo, Akihiro
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.08.2024; BioMed Central; BMC
• Subjects: Adult; Aged; Aged, 80 and over; Analysis; Bone surgery; Bone tumors; Bones; Cancer; Care and treatment; Chemotherapy; Chest; Chest wall; Complications and side effects; Defects; Female; Flap; Health aspects; Hospitals; Humans; Male; Malignant; Metastasis; Middle Aged; Multivariate analysis; Patients; Plastic Surgery Procedures - adverse effects; Plastic Surgery Procedures - methods; Polymethyl methacrylate; Polymethylmethacrylate; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Radiation therapy; Reconstruction; Respiration; Respiratory complication; Respiratory tract diseases; Retrospective Studies; Risk Factors; Sarcoma; Scoliosis; Skin; Surgical complication; Surgical Flaps; Thoracic Neoplasms - pathology; Thoracic Neoplasms - surgery; Thoracic tumors; Thoracic Wall - pathology; Thoracic Wall - surgery; Tumors; Young Adult; Japan; Reconstruction; Respiratory complication; Flap; Surgical complication; FEV1.0; Malignant; Chest wall
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-024-12690-z

Malignant chest wall tumors need to be excised with wide resection to ensure tumor free margins, and the reconstruction method should be selected according to the depth and dimensions of the tumor. Vascularized tissue is needed to cover the superficial soft tissue defect or bone tissue defect. This study evaluated differences in complications according to reconstruction strategy. Forty-five patients with 52 operations for resection of malignant tumors in the chest wall were retrospectively reviewed. Patients were categorized as having superficial tumors, comprising Group A with simple closure for small soft tissue defects and Group B with flap coverage for wide soft tissue defects, or deep tumors, comprising Group C with full-thickness resection with or without mesh reconstruction and Group D with full-thickness resection covered by flap with or without polymethyl methacrylate. Complications were evaluated for the 52 operations based on reconstruction strategy then risk factors for surgical and respiratory complications were elucidated. Total local recurrence-free survival rates in 45 patients who received first operation were 83.9% at 5 years and 70.6% at 10 years. The surgical complication rate was 11.5% (6/52), occurring only in cases with deep tumors, predominantly from Group D. Operations needing chest wall reconstruction (p = 0.0016) and flap transfer (p = 0.0112) were significantly associated with the incidence of complications. Operations involving complications showed significantly larger tumors, wider areas of bony chest wall resection and greater volumes of bleeding (p < 0.005). Flap transfer was the only significant predictor identified from multivariate analysis (OR: 10.8, 95%CI: 1.05-111; p = 0.0456). The respiratory complication rate was 13.5% (7/52), occurring with superficial and deep tumors, particularly Groups B and D. Flap transfer was significantly associated with the incidence of respiratory complications (p < 0.0005). Cases in the group with respiratory complications were older, more frequently had a history of smoking, had lower FEV1.0% and had a wider area of skin resected compared to cases in the group without respiratory complications (p < 0.05). Preoperative FEV1.0% was the only significant predictor identified from multivariate analysis (OR: 0.814, 95%CI: 0.693-0.957; p = 0.0126). Surgical complications were more frequent in Group D and after operations involving flap transfer. Severe preoperative FEV1.0% was associated with respiratory complications even in cases of superficial tumors with flap transfer.