The suppression of inflammatory macrophage-mediated cytotoxicity and proinflammatory cytokine production by transgenic expression of HLA-E

• Published in: Transplant immunology Vol. 29; no. 1; pp. 76 - 81
• Main Authors: Maeda, Akira, Kawamura, Takuji, Ueno, Takehisa, Usui, Noriaki, Eguchi, Hiroshi, Miyagawa, Shuji
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2013
• Subjects: Allergy and Immunology; Animals; CD47 Antigen - genetics; CD47 Antigen - immunology; CD47 Antigen - metabolism; Cell Line; Cytokines - biosynthesis; Cytokines - genetics; Cytokines - immunology; Endothelial Cells - immunology; Endothelial Cells - metabolism; Endothelial Cells - pathology; Gene Expression; Heterografts; Histocompatibility Antigens Class I - biosynthesis; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class I - immunology; HLA-E; HLA-E Antigens; Humans; Immunoreceptor tyrosine-based inhibition motif (ITIM); Inflammation; Inflammation Mediators - immunology; Inflammation Mediators - metabolism; Inflammatory macrophage; Macrophages - immunology; Macrophages - metabolism; Macrophages - pathology; Organ Transplantation; Pro-inflammatory cytokine; Swine; Transgenes; Transplantation Tolerance; Xenocytotoxicity; Pro-inflammatory cytokine; Inflammatory macrophage; Xenocytotoxicity; Immunoreceptor tyrosine-based inhibition motif (ITIM); HLA-E

Abstract Background Macrophages participate in xenogenic rejection and represent a major biological obstacle to successful xenotransplantation. The signal inhibitory regulatory protein α (SIRPα) receptor was reported to be a negative regulator of macrophage phagocytic activity via interaction with C...