Pulmonary Arterial Pressure Changes Under Dobutamine Stress Echocardiography in Non-Anemic Iron Deficient COPD Subjects
Purpose: Non-anemic iron deficiency (NAID) is common in COPD, and could induce functional/structural changes in the pulmonary vascular bed. Thus, we aimed to study, during resting and ambient oxygen conditions, the systolic pulmonary arterial pressure (sPAP) changes during dobutamine stress echocard...
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| Published in | International journal of chronic obstructive pulmonary disease Vol. 17; pp. 1943 - 1949 |
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| Language | English |
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Dove Medical Press Limited
01.01.2022
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| Abstract | Purpose: Non-anemic iron deficiency (NAID) is common in COPD, and could induce functional/structural changes in the pulmonary vascular bed. Thus, we aimed to study, during resting and ambient oxygen conditions, the systolic pulmonary arterial pressure (sPAP) changes during dobutamine stress echocardiography (DSE) for NAID+ compared to NAID- subjects with COPD. Patients and Methods: We analyzed 24 patients with COPD and evaluated their clinical parameters, including lung function and serum iron profile, followed by the changes in the sPAP under DSE. Results: Ten subjects with NAID+ were compared with fourteen NAID- subjects for sPAP measurement. At baseline, only left atrial volume was significantly different between groups (30 [+ or -] 4 vs 23 [+ or -] 5 mL*m2), respectively (p-value=0.002). For the right side, tricuspid annular plane systolic excursion (TAPSE) was similar between-groups (22 [+ or -] 2 vs 20 [+ or -] 4, p-value >0.05), at baseline. The sPAP (mmHg) changes were also not significantly different between groups (pre 32 [+ or -] 14 vs peak 48 [+ or -] 14 for NAID+ and pre 29 [+ or -] 7 vs peak 43 [+ or -] 10 for NAID-, Group p-value=0.400, Time p-value <0.0001, and Interaction p-value=0.606). Conclusion: COPD subjects with NAID do not show increased sPAP responses during DSE, compared with iron-replete subjects. Keywords: COPD, iron deficiency, pulmonary hypertension, stress echocardiography |
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| AbstractList | Purpose: Non-anemic iron deficiency (NAID) is common in COPD, and could induce functional/structural changes in the pulmonary vascular bed. Thus, we aimed to study, during resting and ambient oxygen conditions, the systolic pulmonary arterial pressure (sPAP) changes during dobutamine stress echocardiography (DSE) for NAID+ compared to NAID- subjects with COPD. Patients and Methods: We analyzed 24 patients with COPD and evaluated their clinical parameters, including lung function and serum iron profile, followed by the changes in the sPAP under DSE. Results: Ten subjects with NAID+ were compared with fourteen NAID- subjects for sPAP measurement. At baseline, only left atrial volume was significantly different between groups (30± 4 vs 23± 5 mL*m2), respectively (p-value=0.002). For the right side, tricuspid annular plane systolic excursion (TAPSE) was similar between-groups (22± 2 vs 20± 4, p-value > 0.05), at baseline. The sPAP (mmHg) changes were also not significantly different between groups (pre 32± 14 vs peak 48± 14 for NAID+ and pre 29± 7 vs peak 43± 10 for NAID-, Group p-value=0.400, Time p-value < 0.0001, and Interaction p-value=0.606). Conclusion: COPD subjects with NAID do not show increased sPAP responses during DSE, compared with iron-replete subjects. Purpose: Non-anemic iron deficiency (NAID) is common in COPD, and could induce functional/structural changes in the pulmonary vascular bed. Thus, we aimed to study, during resting and ambient oxygen conditions, the systolic pulmonary arterial pressure (sPAP) changes during dobutamine stress echocardiography (DSE) for NAID+ compared to NAID- subjects with COPD. Patients and Methods: We analyzed 24 patients with COPD and evaluated their clinical parameters, including lung function and serum iron profile, followed by the changes in the sPAP under DSE. Results: Ten subjects with NAID+ were compared with fourteen NAID- subjects for sPAP measurement. At baseline, only left atrial volume was significantly different between groups (30 [+ or -] 4 vs 23 [+ or -] 5 mL*m2), respectively (p-value=0.002). For the right side, tricuspid annular plane systolic excursion (TAPSE) was similar between-groups (22 [+ or -] 2 vs 20 [+ or -] 4, p-value >0.05), at baseline. The sPAP (mmHg) changes were also not significantly different between groups (pre 32 [+ or -] 14 vs peak 48 [+ or -] 14 for NAID+ and pre 29 [+ or -] 7 vs peak 43 [+ or -] 10 for NAID-, Group p-value=0.400, Time p-value <0.0001, and Interaction p-value=0.606). Conclusion: COPD subjects with NAID do not show increased sPAP responses during DSE, compared with iron-replete subjects. Keywords: COPD, iron deficiency, pulmonary hypertension, stress echocardiography Non-anemic iron deficiency (NAID) is common in COPD, and could induce functional/structural changes in the pulmonary vascular bed. Thus, we aimed to study, during resting and ambient oxygen conditions, the systolic pulmonary arterial pressure (sPAP) changes during dobutamine stress echocardiography (DSE) for NAID+ compared to NAID- subjects with COPD.PurposeNon-anemic iron deficiency (NAID) is common in COPD, and could induce functional/structural changes in the pulmonary vascular bed. Thus, we aimed to study, during resting and ambient oxygen conditions, the systolic pulmonary arterial pressure (sPAP) changes during dobutamine stress echocardiography (DSE) for NAID+ compared to NAID- subjects with COPD.We analyzed 24 patients with COPD and evaluated their clinical parameters, including lung function and serum iron profile, followed by the changes in the sPAP under DSE.Patients and MethodsWe analyzed 24 patients with COPD and evaluated their clinical parameters, including lung function and serum iron profile, followed by the changes in the sPAP under DSE.Ten subjects with NAID+ were compared with fourteen NAID- subjects for sPAP measurement. At baseline, only left atrial volume was significantly different between groups (30±4 vs 23±5 mL*m2), respectively (p-value=0.002). For the right side, tricuspid annular plane systolic excursion (TAPSE) was similar between-groups (22±2 vs 20±4, p-value >0.05), at baseline. The sPAP (mmHg) changes were also not significantly different between groups (pre 32±14 vs peak 48±14 for NAID+ and pre 29±7 vs peak 43±10 for NAID-, Group p-value=0.400, Time p-value <0.0001, and Interaction p-value=0.606).ResultsTen subjects with NAID+ were compared with fourteen NAID- subjects for sPAP measurement. At baseline, only left atrial volume was significantly different between groups (30±4 vs 23±5 mL*m2), respectively (p-value=0.002). For the right side, tricuspid annular plane systolic excursion (TAPSE) was similar between-groups (22±2 vs 20±4, p-value >0.05), at baseline. The sPAP (mmHg) changes were also not significantly different between groups (pre 32±14 vs peak 48±14 for NAID+ and pre 29±7 vs peak 43±10 for NAID-, Group p-value=0.400, Time p-value <0.0001, and Interaction p-value=0.606).COPD subjects with NAID do not show increased sPAP responses during DSE, compared with iron-replete subjects.ConclusionCOPD subjects with NAID do not show increased sPAP responses during DSE, compared with iron-replete subjects. Ana Christina Wanderley Xavier,1,2 Rodrigo Koch,1 Leandro Steinhorst Goelzer,1 Paulo T Muller1 1Federal University of Mato Grosso do Sul (UFMS)/Maria Aparecida Pedrossian Hospital (HUMAP), Laboratory of Respiratory Pathophysiology (LAFIR), Campo Grande, Mato Grosso do Sul, MS, Brazil; 2Echocardiography Unit, Maria Aparecida Pedrossian Hospital (HUMAP), Campo Grande, Mato Grosso do Sul, MS, BrazilCorrespondence: Paulo T Muller, Laboratory of Respiratory Pathophysiology (LAFIR), Respiratory Division of University Hospital, Federal University of Mato Grosso do Sul (UFMS), Filinto Müller S/N, Vila Ipiranga, Campo Grande, CEP:79080-090, Brazil, Tel +55-67 33453149, Fax +55-67 33453049, Email paulo.muller@ufms.brPurpose: Non-anemic iron deficiency (NAID) is common in COPD, and could induce functional/structural changes in the pulmonary vascular bed. Thus, we aimed to study, during resting and ambient oxygen conditions, the systolic pulmonary arterial pressure (sPAP) changes during dobutamine stress echocardiography (DSE) for NAID+ compared to NAID- subjects with COPD.Patients and Methods: We analyzed 24 patients with COPD and evaluated their clinical parameters, including lung function and serum iron profile, followed by the changes in the sPAP under DSE.Results: Ten subjects with NAID+ were compared with fourteen NAID- subjects for sPAP measurement. At baseline, only left atrial volume was significantly different between groups (30± 4 vs 23± 5 mL*m2), respectively (p-value=0.002). For the right side, tricuspid annular plane systolic excursion (TAPSE) was similar between-groups (22± 2 vs 20± 4, p-value > 0.05), at baseline. The sPAP (mmHg) changes were also not significantly different between groups (pre 32± 14 vs peak 48± 14 for NAID+ and pre 29± 7 vs peak 43± 10 for NAID-, Group p-value=0.400, Time p-value < 0.0001, and Interaction p-value=0.606).Conclusion: COPD subjects with NAID do not show increased sPAP responses during DSE, compared with iron-replete subjects.Keywords: COPD, iron deficiency, pulmonary hypertension, stress echocardiography |
| Audience | Academic |
| Author | Koch, Rodrigo Muller, Paulo T Steinhorst Goelzer, Leandro Wanderley Xavier, Ana Christina |
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| Cites_doi | 10.3390/biomedicines9091191 10.1073/pnas.1822010116 10.7150/ijms.46163 10.1016/j.echo.2005.10.005 10.1590/S0100-879X1999000600008 10.1590/s1806-37132007000400008 10.1016/j.rmed.2018.10.014 10.1002/ejhf.938 10.1111/resp.12591 10.2147/COPD.S182700 10.14814/phy2.14164 10.1016/j.cardfail.2021.03.010 10.1164/rccm.200806-953OC 10.4103/jcecho.jcecho_4_21 10.3390/jcm10173972 10.1016/j.hlc.2016.04.020 10.1136/bmjopen-2015-007911 10.1111/resp.12772 10.1136/bmjresp-2020-000577 10.1016/j.echo.2007.07.003 10.1183/09031936.05.00034805 10.1378/chest.13-2300 10.1164/rccm.200904-0563OC |
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| Snippet | Purpose: Non-anemic iron deficiency (NAID) is common in COPD, and could induce functional/structural changes in the pulmonary vascular bed. Thus, we aimed to... Non-anemic iron deficiency (NAID) is common in COPD, and could induce functional/structural changes in the pulmonary vascular bed. Thus, we aimed to study,... Ana Christina Wanderley Xavier,1,2 Rodrigo Koch,1 Leandro Steinhorst Goelzer,1 Paulo T Muller1 1Federal University of Mato Grosso do Sul (UFMS)/Maria Aparecida... |
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| StartPage | 1943 |
| SubjectTerms | Blood pressure Cardiac glycosides Cardiotonic agents Chronic obstructive pulmonary disease Comorbidity Comparative analysis copd Dobutamine Echocardiography Exercise Heart rate Hypertension Hypoxia Iron iron deficiency Lung diseases, Obstructive Physical fitness Pulmonary hypertension Short Report stress echocardiography Velocity |
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| Title | Pulmonary Arterial Pressure Changes Under Dobutamine Stress Echocardiography in Non-Anemic Iron Deficient COPD Subjects |
| URI | https://www.proquest.com/docview/2715113527 https://www.proquest.com/docview/2708736552 https://pubmed.ncbi.nlm.nih.gov/PMC9420441 https://doaj.org/article/4e8b1686f1be4b90844085edbce92414 |
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