Pulmonary Arterial Pressure Changes Under Dobutamine Stress Echocardiography in Non-Anemic Iron Deficient COPD Subjects

• Published in: International journal of chronic obstructive pulmonary disease Vol. 17; pp. 1943 - 1949
• Main Authors: Xavier, Ana Christina Wanderley, Koch, Rodrigo, Goelzer, Leandro Steinhorst, Muller, Paulo T
• Format: Journal Article
• Language: English
• Published: London Dove Medical Press Limited 01.01.2022; Dove Medical Press Ltd; Dove; Dove Medical Press
• Subjects: Blood pressure; Cardiac glycosides; Cardiotonic agents; Chronic obstructive pulmonary disease; Comorbidity; Comparative analysis; copd; Dobutamine; Echocardiography; Exercise; Heart rate; Hypertension; Hypoxia; Iron; iron deficiency; Lung diseases, Obstructive; Physical fitness; Pulmonary hypertension; Short Report; stress echocardiography; Velocity; Brazil
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/COPD.S365461

Purpose: Non-anemic iron deficiency (NAID) is common in COPD, and could induce functional/structural changes in the pulmonary vascular bed. Thus, we aimed to study, during resting and ambient oxygen conditions, the systolic pulmonary arterial pressure (sPAP) changes during dobutamine stress echocardiography (DSE) for NAID+ compared to NAID- subjects with COPD. Patients and Methods: We analyzed 24 patients with COPD and evaluated their clinical parameters, including lung function and serum iron profile, followed by the changes in the sPAP under DSE. Results: Ten subjects with NAID+ were compared with fourteen NAID- subjects for sPAP measurement. At baseline, only left atrial volume was significantly different between groups (30 [+ or -] 4 vs 23 [+ or -] 5 mL*m2), respectively (p-value=0.002). For the right side, tricuspid annular plane systolic excursion (TAPSE) was similar between-groups (22 [+ or -] 2 vs 20 [+ or -] 4, p-value >0.05), at baseline. The sPAP (mmHg) changes were also not significantly different between groups (pre 32 [+ or -] 14 vs peak 48 [+ or -] 14 for NAID+ and pre 29 [+ or -] 7 vs peak 43 [+ or -] 10 for NAID-, Group p-value=0.400, Time p-value <0.0001, and Interaction p-value=0.606). Conclusion: COPD subjects with NAID do not show increased sPAP responses during DSE, compared with iron-replete subjects. Keywords: COPD, iron deficiency, pulmonary hypertension, stress echocardiography