Preoperative platelet distribution width predicts bone metastasis in patients with breast cancer

• Published in: BMC cancer Vol. 24; no. 1; pp. 1066 - 7
• Main Authors: Song, Mei-Yue, Zhao, Lin, Huang, Wen-Juan, Cui, Ming-Ming, Liu, Yu-Xi, Wang, Rui-Tao, Zhang, Xin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.08.2024; BioMed Central; BMC
• Subjects: Adult; Aged; Analysis; Blood platelets; Blood Platelets - pathology; Bone cancer; Bone metastasis; Bone Neoplasms - blood; Bone Neoplasms - secondary; Bone surgery; Breast cancer; Breast Neoplasms - blood; Breast Neoplasms - pathology; Cancer; Cancer patients; Cancer therapies; Care and treatment; Development and progression; Diagnosis; Disease susceptibility; Endothelium; Female; Females; Growth factors; Health aspects; Hemoglobin; Hospitals; Humans; Kaplan-Meier Estimate; Lymph nodes; Lymphatic system; Measurement; Medical colleges; Medical prognosis; Metastases; Metastasis; Middle Aged; Multivariate analysis; Oncology, Experimental; Ovarian cancer; Patients; Platelet Count; Platelet distribution width; Platelets; Preoperative Period; Prognosis; Retrospective Studies; Risk Factors; Surgery; Tomography; China; Canada; United Kingdom; Bone metastasis; Breast cancer; Platelet distribution width
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-024-12837-y

Bone metastases occur in 50-70% of patients with breast cancer (BC) and result in high mortality. Platelet distribution width (PDW), a commonly used parameter of activated platelets, has been associated with a poor prognosis in BC. We aim to investigate the prognostic role of PDW for bone metastasis in BC patients. 515 patients who received BC surgery in the Harbin Medical University Cancer Hospital from July 1, 2016, to December 31, 2017, were reviewed. Patients' characteristics and platelet indices upon enrollment in this study were collected. The Kaplan-Meier method was used to estimate the 5-year bone metastasis incidence. The univariate and multivariate Cox regression analyses were utilized to identify risk factors associated with bone metastasis. The patients with bone metastases exhibited lower PDW levels than the patients without bone metastases. Moreover, decreased PDW was significantly correlated with histologic type, multifocal disease, and lymph node status. In addition, the patients with reduced PDW levels were more likely to develop bone metastasis. Multivariate analysis showed that PDW was an independent predictor for bone metastasis. PDW is an independent predictor of bone metastasis in BC. Further research is warranted.