Telomerase and the maintenance of chromosome ends

The catalytic subunit of telomerase has recently been identified in diverse eukaryotes and shown to be a reverse transcriptase. Ectopic expression of this protein in normal human cells leads to lengthened telomeres and an extended in vitro life span. Other proteins that modulate telomerase activity...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 11; no. 3; pp. 318 - 324
Main Authors Bryan, Tracy M, Cech, Thomas R
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.1999
Subjects
Animals
Humans
Telomerase - metabolism
Telomere - enzymology
Telomere - genetics
RT
PARP
PD
TERT
EST2
TRF1
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Summary:The catalytic subunit of telomerase has recently been identified in diverse eukaryotes and shown to be a reverse transcriptase. Ectopic expression of this protein in normal human cells leads to lengthened telomeres and an extended in vitro life span. Other proteins that modulate telomerase activity in vivo are also being identified, including a functionally conserved family of proteins with Myb-like DNA-binding domains and proteins that are involved in DNA double-strand break repair.
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ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(99)80043-X