Timing of clinic visits after health checks and risk of hospitalization for cardiovascular events and all-cause death among the high-risk population

• Published in: Atherosclerosis Vol. 388; p. 117409
• Main Authors: Dong, Jia-Yi, Iso, Hiroyasu, Muraki, Isao, Tanaka, Mari, Imano, Hironori
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.01.2024
• Subjects: Adult; Ambulatory Care; Cardiovascular disease; Clinic visit; Cohort study; Coronary Disease; Health checks; Health claims data; Heart Failure - diagnosis; Heart Failure - therapy; Hospitalization; Humans; Preventive medicine; Real-world evidence; Stroke - diagnosis; Stroke - epidemiology; Stroke - therapy; Health claims data; Clinic visit; Cohort study; Cardiovascular disease; Preventive medicine; Health checks; Real-world evidence
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2023.117409

We aimed to examine the association between timing of clinic visits after health checks and risk of hospitalization for cardiovascular events and all-cause mortality among the high-risk population. A total of 412,059 high-risk individuals from the health claims database of the Japan Health Insurance Association were divided into 4 groups according to the timing of clinic visits during 12 months after health checks (early: <3 months, intermediate: 4–6 months, late: 7–12 months, and none). Cox proportional hazard regression models were used to examine the associations between timing of clinic visits after health checks and risk of hospitalization for stroke, coronary heart disease, heart failure, or all-cause mortality. During a median follow-up of 4.3 years, we identified a total of 15,860 cases having composite outcomes of first hospitalization for stroke, coronary heart disease, heart failure, or all-cause mortality. Compared to high-risk adults without clinic visits after the health checks, the fully adjusted hazard ratios (95% confidence interval) of a composite outcome were 0.78 (0.74, 0.81), 0.84 (0.78, 0.89), and 0.94 (0.89, 1.00) for early, intermediate, and late clinic visits, respectively. Compared to no clinic visit, an early clinic visit was associated with lower risks of all individual endpoints, and the risk reductions appeared to be greater in the hospitalization for stroke and heart failure. The present study using real-world data provided evidence that an early clinic visit after health checks was associated with lower risks of hospitalization for major cardiovascular events and all-cause mortality among high-risk individuals. [Display omitted] •The association between timing of clinic visits and cardiovascular risk is unclear.•Our study had a large sample size of 0.4 million high-risk people.•An early clinic visit was associated with a reduced risk of cardiovascular events.