New insights into the impact of the intestinal microbiota on health and disease: a symposium report

• Published in: British journal of nutrition Vol. 107; no. S1; pp. S1 - S13
• Main Authors: Thomas, Linda V., Ockhuizen, Theo
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.01.2012
• Subjects: Adjuvants, Immunologic; animal models; Animals; Anti-Bacterial Agents; Antibiotics; Athletes; bacteria; Bacteria - classification; Bacteria - genetics; Biological and medical sciences; Biology; Biomarkers; Carbohydrates; Colorectal carcinoma; colorectal neoplasms; Diet; dietary supplements; Disease; Exercise; Feeding. Feeding behavior; Food; Fundamental and applied biological sciences. Psychology; Gastrointestinal Diseases - microbiology; Gastrointestinal Diseases - prevention & control; Gastrointestinal tract; Genome, Bacterial; Genomics; health effects assessments; Health risks; Homeostasis; Humans; Immune response; Immune system; intestinal microorganisms; intestinal mucosa; Intestines - immunology; Intestines - metabolism; Intestines - microbiology; Irritable bowel syndrome; Metabolism; metagenomics; Microbiota; Nutrition; Phylogeny; Physiology; Probiotics; therapeutics; vaccine adjuvants; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Western diets; Netherlands; China; Probiotics; Immune function; Intestinal microbiota; Health and disease; Vertebrata; Mammalia
• ISSN: 0007-1145; 1475-2662; 1475-2662
• DOI: 10.1017/S0007114511006970

The present report summarises key insights from a recent symposium focusing on the impact of the intestinal microbiota on health and disease. A more appropriate definition of health was proposed since health maintenance is a dynamic process better assessed in terms of ability to adapt to stress and maintain physiological homeostasis. Biomarkers specifically for health are needed; use of challenge models and subjects with suboptimal health or specific disease risk were advised. The complexity of interactions between external factors, the intestinal epithelium, intestinal microbiota, the immune system and health was exemplified by describing the effects of antibiotics, the Western diet and non-digestible carbohydrates on the microbiota. The association of certain bacteria with different states of health or disease was acknowledged but also that is not always clear whether this is a cause or effect. Recent identification of three robust faecal metagenome clusters may advance this understanding. It was speculated that knowledge of the intestinal microbiota profile may eventually help in the diagnosis of health risks and choice of therapy. It was agreed that beneficial manipulation of the commensal microbiota can improve health outcome. For this purpose, three areas were reviewed. Firstly, research into probiotics as vaccine adjuvants was considered useful for substantiation of immune function claims. Secondly, positive results with certain probiotics and synbiotics for colorectal cancer are emerging, mostly from in vitro and animal studies. Finally, studies in endurance athletes have shown strain-specific probiotic benefit in terms of maintenance of immune function and, for certain strains, reduction of episodes of respiratory and/or gastrointestinal tract infections.