Low neutrophil-to-lymphocyte ratio and pan-immune-inflammation-value predict nodal pathologic complete response in 1274 breast cancer patients treated with neoadjuvant chemotherapy: a multicenter analysis

• Published in: Therapeutic advances in medical oncology Vol. 15; p. 17588359231193732
• Main Authors: Gasparri, Maria Luisa, Albasini, Sara, Truffi, Marta, Favilla, Karin, Tagliaferri, Barbara, Piccotti, Francesca, Bossi, Daniela, Armatura, Giulia, Calcinotto, Arianna, Chiappa, Corrado, Combi, Francesca, Curcio, Annalisa, Della Valle, Angelica, Ferrari, Guglielmo, Folli, Secondo, Ghilli, Matteo, Listorti, Chiara, Mancini, Stefano, Marinello, Peter, Mele, Simone, Pertusati, Anna, Roncella, Manuela, Rossi, Lorenzo, Rovera, Francesca, Segattini, Silvia, Sgarella, Adele, Tognali, Daniela, Corsi, Fabio
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2023; Sage Publications Ltd; SAGE Publishing
• Subjects: Breast cancer; Chemotherapy; ErbB-2 protein; Estrogen receptors; Inflammation; Leukocytes (neutrophilic); Lymphocytes; Multivariate analysis; Neutrophils; Original Research; inflammatory markers; sentinel lymph node biopsy; pan-immune-inflammation value; axillary surgery; breast cancer; neutrophil–lymphocyte ratio; axillary dissection
• ISSN: 1758-8359; 1758-8340; 1758-8359
• DOI: 10.1177/17588359231193732

Background: Systemic inflammatory markers draw great interest as potential blood-based prognostic factors in several oncological settings. Objectives: The aim of this study is to evaluate whether neutrophil-to-lymphocyte ratio (NLR) and pan-immune-inflammation value (PIV) predict nodal pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in node-positive (cN+) breast cancer (BC) patients. Design: Clinically, cN+ BC patients undergoing NAC followed by breast and axillary surgery were enrolled in a multicentric study from 11 Breast Units. Methods: Pretreatment blood counts were collected for the analysis and used to calculate NLR and PIV. Logistic regression analyses were performed to evaluate independent predictors of nodal pCR. Results: A total of 1274 cN+ BC patients were included. Nodal pCR was achieved in 586 (46%) patients. At multivariate analysis, low NLR [odds ratio (OR) = 0.71; 95% CI, 0.51–0.98; p = 0.04] and low PIV (OR = 0.63; 95% CI, 0.44–0.90; p = 0.01) were independently predictive of increased likelihood of nodal pCR. A sub-analysis on cN1 patients (n = 1075) confirmed the statistical significance of these variables. PIV was significantly associated with axillary pCR in estrogen receptor (ER)−/human epidermal growth factor receptor 2 (HER2)+ (OR = 0.31; 95% CI, 0.12–0.83; p = 0.02) and ER−/HER2− (OR = 0.41; 95% CI, 0.17–0.97; p = 0.04) BC patients. Conclusion: This study found that low NLR and PIV levels predict axillary pCR in patients with BC undergoing NAC. Registration: Eudract number NCT05798806.