Autophagy: Self-preservation through cannibalism of proteins and organelles

The recent excitement about autophagy research is justified; the importance of the pathobiology of this process is obvious. Clearly, functional autophagy is central to basic cellular housekeeping and recycling activity, maintenance of homeostasis, and injury response. An improved understanding of th...

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Published inSurgery Vol. 157; no. 1; pp. 1 - 5
Main Authors Vlada, Claudiu A., MD, Kim, Jae-Sung, PhD, Behrns, Kevin E., MD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 2015
Subjects
Animals
Autophagy
Humans
Liver - physiology
Organelles - metabolism
Proteins - metabolism
Surgery
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Summary:The recent excitement about autophagy research is justified; the importance of the pathobiology of this process is obvious. Clearly, functional autophagy is central to basic cellular housekeeping and recycling activity, maintenance of homeostasis, and injury response. An improved understanding of the autophagic process should lead to potentially innovative therapies with direct relevance to surgical diseases. Although autophagy has been one of nature's closely guarded secrets until recently, an abundance of new findings provides substantial promise for therapeutic manipulation of this endogenous process. Stay tuned as we discover and use new therapeutics to take advantage of autophagy in the management of surgery patients.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0039-6060
1532-7361
DOI:10.1016/j.surg.2014.07.014