Timing temporal transitions during brain development

Highlights • Temporal patterning of neural progenitors is a conserved strategy to generate cell diversity. • In Drosophila , tTFs deterministically regulate cell fate. • In vertebrates, tTFs bias stochastic cell-fate decisions towards specific fates. • Intrinsic and extrinsic cues can regulate tempo...

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Bibliographic Details
Published inCurrent opinion in neurobiology Vol. 42; pp. 84 - 92
Main Authors Rossi, Anthony M, Fernandes, Vilaiwan M, Desplan, Claude
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2017
Subjects
Animals
Biological Evolution
Brain - cytology
Brain - embryology
Invertebrates - embryology
Neural Stem Cells - cytology
Neurology
Neurons - cytology
Psychiatry
Time Factors
Vertebrates - embryology
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Summary:Highlights • Temporal patterning of neural progenitors is a conserved strategy to generate cell diversity. • In Drosophila , tTFs deterministically regulate cell fate. • In vertebrates, tTFs bias stochastic cell-fate decisions towards specific fates. • Intrinsic and extrinsic cues can regulate temporal transitions.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Authors contributed equally
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2016.11.010