Aliphatic and Olefinic Fat Suppression in the Orbit Using Polarity-altered Spectral and Spatial Selective Acquisition (PASTA) with Opposed Phase

• Published in: Magnetic Resonance in Medical Sciences Vol. 23; no. 2; pp. 193 - 203
• Main Authors: Malis, Vadim, Bae, Won C., Yamamoto, Asako, Kassai, Yoshimori, McDonald, Marin A, Miyazaki, Mitsue
• Format: Journal Article
• Language: English
• Published: Japan Japanese Society for Magnetic Resonance in Medicine 01.01.2024; Japan Science and Technology Agency
• Subjects: Adipose Tissue - diagnostic imaging; aliphatic and olefinic fat; Aliphatic compounds; Alkenes; Chemical equilibrium; Data acquisition; fat suppression; Fatty acid composition; Fish oils; Humans; Image acquisition; Image resolution; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetic Resonance Spectroscopy; Major Paper; Muscles; Nerves; NMR; Nuclear magnetic resonance; Orbit; Orbits; Phantoms, Imaging; polarity altered spectral and spatial acquisition (PASTA); Protons; unsaturated and saturated chemical shift opposed phase; unsaturated and saturated chemical shift opposed phase; fat suppression; polarity altered spectral and spatial acquisition (PASTA); aliphatic and olefinic fat; orbit
• ISSN: 1347-3182; 1880-2206
• DOI: 10.2463/mrms.mp.2022-0073

Purpose: Fatty acid composition of the orbit makes it challenging to achieve complete fat suppression during orbit MR imaging. Implementation of a fat suppression technique capable of suppressing signals from saturated (aliphatic) and unsaturated (olefinic or protons at double-bonded carbon sites) fat would improve the visualization of an optical nerve. Furthermore, the ability to semi-quantify the fractions of aliphatic and olefinic fat may potentially provide valuable information in assessing orbit pathology.Methods: A phantom study was conducted on various oil samples on a clinical 3 Tesla scanner. The imaging protocol included three 2D fast spin echo (FSE) sequences: in-phase, polarity-altered spectral and spatial selective acquisition (PASTA), and a combination of PASTA with opposed phase in olefinic and aliphatic chemical shift. The results were validated against high-resolution 11.7T NMR and compared with images acquired with spectral attenuated inversion recovery (SPAIR) and chemical shift selective (CHESS) fat suppression techniques. In-vivo data were acquired on eight healthy subjects and were compared with the prior histological studies.Results: PASTA with opposed phase achieved complete suppression of fat signals in the orbits and provided images of well-delineated optical nerves and muscles in all subjects. The olefinic fat fraction in the olive, walnut, and fish oil phantoms at 3T was found to be 5.0%, 11.2%, and 12.8%, respectively, whereas 11.7T NMR provides the following olefinic fat fractions: 6.0% for olive, 11.5% for walnut, and 12.6% for fish oils. For the in-vivo study, on average, olefinic fat accounted for 9.9% ± 3.8% of total fat while the aliphatic fat fraction was 90.1% ± 3.8%, in the normal orbits.Conclusion: We have introduced a new fat suppression technique using PASTA with opposed phase and applied it to human orbits. The purposed method achieves an excellent orbital fat suppression and the quantification of aliphatic and olefinic fat signals.