Lessons from the rifamycin biosynthetic gene cluster

There is currently intense interest in unravelling the modus operandi of type I modular polyketide synthases in order to lay the ground work for their use in the combinatorial biosynthesis of new bioactive molecules. Much of our knowledge is derived from studies on 6-deoxyerythronolide B (DEBS), the...

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Bibliographic Details
Published inCurrent Opinion in Chemical Biology Vol. 3; no. 5; pp. 592 - 597
Main Authors Floss, Heinz G, Yu, Tin-Wein
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.1999
Subjects
DEBS
Models, Chemical
Multienzyme Complexes - metabolism
Multigene Family
PKS
Polyketide
Rifamycin
Rifamycins - biosynthesis
Synthase
Polyketide
PKS
Biochemistry
Rifamycin
Synthase
DEBS
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Summary:There is currently intense interest in unravelling the modus operandi of type I modular polyketide synthases in order to lay the ground work for their use in the combinatorial biosynthesis of new bioactive molecules. Much of our knowledge is derived from studies on 6-deoxyerythronolide B (DEBS), the enzyme assembling the polyketide backbone of erythromycin. Work on the rifamycin polyketide synthase has revealed a number of features that differ from those seen with DEBS.
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ISSN:1367-5931
1879-0402
DOI:10.1016/S1367-5931(99)00014-9