Managing malignant sublingual gland tumors: a single institution experience with 23 patients

• Published in: BMC cancer Vol. 24; no. 1; pp. 1135 - 10
• Main Authors: Zhang, Shi-Long, Wu, Zhou-Yang, Fan, Ren-Xiu, Jia, Jun, Yu, Zi-Li
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.09.2024; BioMed Central; BMC
• Subjects: Adenoid; Adult; Aged; Brachytherapy; Cancer; Carcinoma, Adenoid Cystic - diagnosis; Carcinoma, Adenoid Cystic - pathology; Carcinoma, Adenoid Cystic - surgery; Carcinoma, Adenoid Cystic - therapy; Carcinoma, Mucoepidermoid - pathology; Carcinoma, Mucoepidermoid - surgery; Carcinoma, Mucoepidermoid - therapy; Cardiovascular disease; Care and treatment; Cervical carcinoma; Diagnosis; Dissection; Exocrine glands; Female; Humans; Lymph Node Excision; Lymph nodes; Lymphatic system; Lymphoma; Lymphomas; Male; Malignancy; Maxillofacial; Maxillofacial surgery; Medical diagnosis; Medical imaging; Metastasis; Middle Aged; Mucosal-associated lymphoid tissue; Pathological types; Pathology; Patients; Plastic Surgery Procedures - methods; Primary malignant sublingual gland tumors; Prognosis; Radiation therapy; Radiotherapy; Reconstructive surgery; Retrospective Studies; Salivary gland; Salivary gland tumors; Soft tissue reconstruction; Sublingual Gland Neoplasms - pathology; Sublingual Gland Neoplasms - therapy; Surgical excision prognosis; Tongue; Tumors; Young Adult; China; Primary malignant sublingual gland tumors; Soft tissue reconstruction; Pathological types; Surgical excision prognosis
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-024-12899-y

Due to the relative rarity of malignant sublingual gland tumors, diagnosing and treating them clinically pose challenges. Hence, there's a need to explore the pathological types, characteristics, treatment methods, and prognosis of primary malignant tumors of the sublingual gland to improve our understanding and management of these rare yet highly malignant conditions. This study reviewed cases of primary malignant sublingual gland tumors, analyzing their characteristics. The treatment methods included surgical excision, with additional radiotherapy, or brachytherapy for advanced stages or positive surgical margins. The study also summarized different treatment approaches, including lymph node dissection and soft tissue reconstruction using free flaps such as the anterolateral thigh flap and forearm flap. We have gathered 23 cases of sublingual gland malignancies treated at the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, from January 2013 to May 2024. The most common pathological types were adenoid cystic carcinoma and mucoepidermoid carcinoma, with rare cases of mucosa-associated lymphoid tissue (MALT) lymphoma and nonspecific salivary gland clear cell carcinoma. Early diagnosis and surgical intervention were crucial for a favorable prognosis. Marginal mandibulectomy was necessary for cases involving the mandible. Patients with positive preoperative lymph node detection required cervical lymph node dissection. Extensive tissue defects in the floor of the mouth were effectively reconstructed with free flaps to prevent oral-mandibular fistula. Surgical excision remains the preferred treatment for malignant sublingual gland tumors. Early diagnosis and comprehensive surgical management are essential for improving prognosis. The study's limitations include a small sample size and short follow-up duration, necessitating further research with larger clinical samples to confirm these findings.