The effect of glucose administration on perceived fetal movements in women with decreased fetal movement, a double-blinded placebo-controlled trial

• Published in: Journal of perinatology Vol. 36; no. 8; pp. 598 - 600
• Main Authors: Michaan, N, Baruch, Y, Topilsky, M, Amzalag, S, Iaskov, I, Many, A, Maslovitz, S
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.08.2016; Nature Publishing Group
• Subjects: 692/1807/2782; 692/308/409; 692/700/459/1748; Administration, Intravenous; Adult; Analysis; Blood Glucose - metabolism; Clinical trials; Confidence intervals; Dextrose; Double-Blind Method; Female; Fetal Movement; Fetal movements; Fetuses; Glucose; Glucose - administration & dosage; Gynecology; Health aspects; Humans; Induced labor; Israel; Labor; Maternal-Fetal Exchange; Medicine; Medicine & Public Health; Obstetrics; original-article; Patients; Pediatric Surgery; Pediatrics; Physiological aspects; Placebos; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, Third; Young Adult; Israel; Tel Aviv Israel
• ISSN: 0743-8346; 1476-5543
• DOI: 10.1038/jp.2016.52

Objective: To assess the effect of maternal glucose administration on perceived fetal movements. Study design: This was a randomized, double-blinded placebo-controlled trial. Patients 28–41 weeks singleton gestation complaining of decreased fetal movements (DFM) were assigned to receive either 500 cc dextrose 5% (group A) or 500 cc normal saline (group B) intravenously. Primary outcome was number of fetal movements recorded during the following 30 min. Secondary outcomes included need for admission or induction of labor owing to persistent DFM. Maternal glucose levels were taken before and after intervention. A sample size of 50 patients was planned in order to detect a 30% increase in fetal movements in group A. Results: Between February 2011 and April 2013, 50 patients were recruited. Demographic characteristics were similar among groups. There was no difference in the number of fetal movements recorded (7±6 vs 8.8±6 movements/30 min, group A and B, respectively, P =0.39). Similar number of patients had persistent DFM that required admission (8 vs 10 patients, P =0.77, OR 1.4, confidence interval (CI) 0.38–5.3); of those admitted, similar number of patients had induction of labor (3 vs 6 patients, P =0.64, OR 0.4, CI 0.03–3.8). Maternal glucose levels were similar at recruitment (88±19 vs 83±15 mg dl −1 P =0.36) but were significantly higher in group A (161±37 vs 75±15 mg dl −1 P <0.0001) after intervention. Conclusion: In women with DFM, maternal glucose administration has no effect on perceived fetal movement and its clinical use is questionable.