Protective Effect of Interleukin-4 -589T Polymorphism on Human Immunodeficiency Virus Type 1 Disease Progression: Relationship with Virus Load

• Published in: The Journal of infectious diseases Vol. 185; no. 8; pp. 1183 - 1186
• Main Authors: Nakayama, Emi E., Meyer, Laurence, Iwamoto, Aikichi, Persoz, Anne, Nagai, Yoshiyuki, Rouzioux, Christine, Delfraissy, Jean-François, Debre, Patrice, McIlroy, Dorian, Theodorou, Ioannis, Shioda, Tatsuo
• Format: Journal Article
• Language: English
• Published: Chicago, IL University of Chicago Press 15.04.2002; Oxford University Press
• Subjects: Acquired Immunodeficiency Syndrome - genetics; Acquired Immunodeficiency Syndrome - virology; Adult; AIDS; Alleles; Biological and medical sciences; Concise Communications; Disease progression; Female; HIV; HIV 1; HIV-1 - isolation & purification; Homozygotes; Human immunodeficiency virus 1; Human viral diseases; Humans; Infections; Infectious diseases; Interleukin-4 - genetics; Male; Medical sciences; Polymorphism, Genetic; Protective effects; Receptors, CCR2; Receptors, Chemokine - genetics; RNA; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Viruses; Human; Immunoprotection; Immunopathology; Correlation; HIV-1 virus; Cytokine; Retroviridae; AIDS; Immune deficiency; Lentivirus; Infection; Virus; Allele; Interleukin 4; Viral disease; Evolution; Human immunodeficiency virus; Viral load; Polymorphism
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/339825

The interleukin (IL)-4 -589T allele bears a single nucleotide polymorphism at position -589 upstream from the open-reading frame of the IL-4 gene. To determine the influence of this allele on human immunodeficiency virus (HIV) type 1 disease, disease progression and serum virus load were assessed by IL-4 genotype in 427 white patients with known seroconversion dates who were followed in the French SEROCO cohort between 1988 and 1996. Serum virus load was 0.20 log lower during the 6-24-month plateau phase after seroconversion in patients with IL-4 -589T than in those without this allele (P = .02). Kaplan-Meier analysis survival curves showed a slower progression to clinical AIDS in carriers of IL-4 -589T (P = .04). Adjustment for early serum virus load greatly diminished the strength of this association. These results suggest that IL-4 -589T protects against HIV-1 disease progression by reducing virus load.