Chronic tissue insulin resistance following hemorrhagic shock

Metabolism of fat and muscle tissue was measured for 30 days following shock and reinfusion in rabbits. Tissue insulin resistance in the post-shock period was demonstrated by decreased oxidation of glucose and decreased incorporation of glucose into neutral lipid or glycogen during incubation with i...

Full description

Saved in:
Bibliographic Details
Published inAnnals of surgery Vol. 180; no. 4; pp. 402 - 407
Main Authors Ryan, N T, George, B C, Egdahl, D H, Egdahl, R H
Format Journal Article
LanguageEnglish
Published United States 01.10.1974
Subjects
Adipose Tissue - metabolism
Amino Acids - metabolism
Animals
Carbon Dioxide - metabolism
Carbon Radioisotopes
Female
Glucose - metabolism
Insulin - pharmacology
Insulin Resistance
Leucine - metabolism
Male
Muscles - metabolism
Rabbits
Shock, Hemorrhagic - metabolism
Time Factors
Online AccessGet full text

Cover

More Information
Summary:Metabolism of fat and muscle tissue was measured for 30 days following shock and reinfusion in rabbits. Tissue insulin resistance in the post-shock period was demonstrated by decreased oxidation of glucose and decreased incorporation of glucose into neutral lipid or glycogen during incubation with insulin. In addition, the insulin stimulated incorporation of amino acids into muscle protein was markedly reduced after shock. Conversely, the capacity of muscle to oxidize leucine was enhanced by shock, even in the presence of insulin. Tissue insulin resistance and increased leucine catabolism are likely to contribute to the general metabolic response to shock and trauma.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-197410000-00004