Relationship between inter-arm blood pressure difference and severity of coronary atherosclerosis

• Published in: Atherosclerosis Vol. 263; pp. 171 - 176
• Main Authors: Park, Se-Jun, Son, Jung-Woo, Park, Sang-Min, Choi, Hyun-Hee, Hong, Kyung-Soon
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.08.2017
• Subjects: Aged; Atherosclerosis; Blood Pressure; Cardiovascular; Comorbidity; Coronary Angiography; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - epidemiology; Coronary Artery Disease - physiopathology; Coronary Vessels - diagnostic imaging; Cross-Sectional Studies; Female; Gensini score; Humans; Inter-arm blood pressure difference; Male; Middle Aged; Plaque, Atherosclerotic; Predictive Value of Tests; Prognosis; Republic of Korea - epidemiology; Retrospective Studies; Risk Factors; Severity of Illness Index; Upper Extremity - blood supply; Gensini score; Inter-arm blood pressure difference; Atherosclerosis
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2017.06.023

Abstract Background and aims A greater inter-arm blood pressure difference (IABPD) is associated with atherosclerosis, but its association with coronary artery disease is unknown. We investigated the relationship between IABPD and coronary atherosclerosis. Methods We retrospectively reviewed blood pressure (BP) data that was measured simultaneously in both arms of patients who underwent initial coronary angiography. Coronary atherosclerosis was assessed using the Gensini score, based on quantitative coronary angiography findings. To adjust for the effect of baseline BP, the percentages of systolic IABPD to higher mean BP (cIABPDsys ), diastolic IABPD to higher mean BP (cIABPDdia ), and mean IABPD to higher mean BP (cIABPDmean ) were calculated as BP-adjusted IABPDs. Results We examined the records of 816 patients (516 males, mean age: 65.5 ± 11.8 years). The mean Gensini score was 33.4 ± 30.4, and the median was 25. All cIAPBDs had positive correlations with the Gensini score (cIABPDsys : r = 0.208, p  < 0.001; cIABPDdia : r = 0.123, p  < 0.001; cIABPDmean : r = 0.120, p  = 0.001). Multiple regression analysis indicated that cIABPDsys was associated with the Gensini score, independently of age, gender, smoking, diabetes, hypertension and dyslipidemia (B = 0.031, p  < 0.001). Conclusions The BP-adjusted IABPD parameters are related to the severity of coronary artery disease. Further studies should investigate use of the IABPD to improve management of coronary atherosclerosis.