A randomized double-blind trial to measure the absorption characteristics of eicosapentaenoic acid and docosahexaenoic acid rich oil blend with natural lipid-based delivery system

• Published in: Food science and biotechnology Vol. 33; no. 8; pp. 1957 - 1964
• Main Authors: Chuang, Jennifer, Briskey, David, Dang, Jennifer, Rajgopal, Arun, Rao, Amanda
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.06.2024; Springer Nature B.V; 한국식품과학회
• Subjects: Bioavailability; Chemical kinetics; Chemistry; Chemistry and Materials Science; Docosahexaenoic acid; Drug delivery; Drug delivery systems; Eicosapentaenoic acid; Ethyl esters; Food Science; Lipids; Nutrition; Pharmacokinetics; Research Article; 식품과학; Absorption enhancement; Bioavailability; DHA; Omega-3 fatty acid; EPA
• ISSN: 1226-7708; 2092-6456
• DOI: 10.1007/s10068-023-01466-z

A randomized, double-blinded trial with 65 subjects was conducted to compare the pharmacokinetics between PhytoMarineCelle (PM) that consists of eicosapentaenoic acid and docosahexaenoic acid (EPA + DHA) plus a self-emulsifying drug delivery system (SEDDS), and a standard EPA + DHA ethyl ester (SEE) that does not contain SEDDS. PM showed 1.6-fold greater plasma area under the curve (AUC) than SEE at 300 mg, although no significant difference was observed. PM showed a 3.1 and 3.2-fold ( p  < 0.05) greater plasma AUC than SEE at 500 mg and 1000 mg respectively. The concentration max (Cmax) of EPA + DHA did not change between PM and SEE at 300 mg. Cmax of PM was twofold greater than SEE at 500 mg and 1000 mg respectively. The Cmax of EPA + DHA achieved significant difference ( p  < 0.05) only with the 500 mg dose. The PM formulation increased the bioavailability of EPA + DHA by threefold compared to SEE at 500 and 1000 mg.