Risk factors associated with mortality in patients hospitalized for coronavirus disease 2019 in Rio de Janeiro, Brazil

Understanding the mortality-associated risk factors of coronavirus disease 2019 will impact clinical decisions. This retrospective longitudinal study included patients hospitalized for coronavirus disease in Rio de Janeiro, Brazil. The Kaplan-Meier method and multivariate Cox regression analysis wer...

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Published inRevista da Sociedade Brasileira de Medicina Tropical Vol. 54; pp. e0878 - e2020
Main Authors Correal, Julio César Delgado, Solórzano, Victor Edgar Fiestas, Damasco, Paula Hesselberg, Martins, Maria de Lourdes, Oliveira, Adriana Guerreiro Soares de, Campos, Carla Salles, Fornasari, Marcos Fernando, Azeredo, Elzinandes Leal de, Damasco, Paulo Vieira
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Sociedade Brasileira de Medicina Tropical - SBMT 01.01.2021
Sociedade Brasileira de Medicina Tropical (SBMT)
Subjects
Brazil
Brazil - epidemiology
COVID-19
Humans
Kaplan-Meier analysis
Longitudinal Studies
Mortality
Retrospective Studies
Risk Factors
SARS-CoV-2
Short Communication
TROPICAL MEDICINE
Brazil
COVID-19
Brazil
Kaplan-Meier analysis
Mortality
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Summary:Understanding the mortality-associated risk factors of coronavirus disease 2019 will impact clinical decisions. This retrospective longitudinal study included patients hospitalized for coronavirus disease in Rio de Janeiro, Brazil. The Kaplan-Meier method and multivariate Cox regression analysis were used. Sequential Organ Failure Assessment score of ≥2 (hazard ratio 4.614; 95% confidence interval =2.210-9.634; p<0.001) and neutrophil/lymphocyte ratio of >5 (hazard ratio=2.616; 95% confidence interval=1.303-5.252; p=0.007) were independently associated with mortality. Sequential Organ Failure Assessment score and neutrophil/lymphocyte ratio on admission can identify coronavirus disease patients at increased risk of death and guide subsequent clinical decisions.
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These authors contributed equally to this work
Conflict of Interest: The authors declare no conflict of interest.
Authors’ contribution: JCDC and VEFS: designed the study and wrote the manuscript; PVD: implemented the study; JCDC, VEFS, PHD and MLM: collected the data; JCDC and VEFS: performed the statistical analysis. All authors contributed to and approved the final manuscript.
ISSN:0037-8682
1678-9849
1678-9849
DOI:10.1590/0037-8682-0878-2020