Next Generation Sequencing in Adult B Cell Acute Lymphoblastic Leukemia Patients

Highlights • NGS of IgH VDJ in adult ALL is an accurate and sensitive measure of MRD. • Patients MRD negative by NGS and MFC have superior outcome vs. cases MRD positive. • Peripheral blood testing for MRD in ALL may complement BM testing.

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Bibliographic Details
Published inBiology of blood and marrow transplantation Vol. 23; no. 4; pp. 691 - 696
Main Authors Torra, Olga Sala, MD, Othus, Megan, PhD, Williamson, David W., PhD, Wood, Brent, MD, PhD, Kirsch, Ilan, MD, Robins, Harlan, PhD, Beppu, Lan, BS, O'Donnell, Margaret R., MD, Forman, Stephen J., MD, Appelbaum, Frederick R., MD, Radich, Jerald P., MD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2017
Subjects
Acute lymphoblastic leukemia
Adolescent
Adult
B-Lymphocytes - pathology
Bone Marrow - pathology
Flow Cytometry
Hematology, Oncology and Palliative Medicine
High-Throughput Nucleotide Sequencing - methods
Humans
Immunoglobulins - genetics
Middle Aged
Minimal residual disease
Neoplasm, Residual - diagnosis
Neoplasm, Residual - genetics
Peripheral Blood Stem Cells - pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Young Adult
Acute lymphoblastic leukemia
minimal residual disease
Minimal residual disease
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Summary:Highlights • NGS of IgH VDJ in adult ALL is an accurate and sensitive measure of MRD. • Patients MRD negative by NGS and MFC have superior outcome vs. cases MRD positive. • Peripheral blood testing for MRD in ALL may complement BM testing.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1083-8791
1523-6536
DOI:10.1016/j.bbmt.2016.12.639