Pheophorbide a : State of the Art

Chlorophyll breakdown products are usually studied for their antioxidant and anti-inflammatory activities. The chlorophyll derivative Pheophorbide (PPB ) is a photosensitizer that can induce significant anti-proliferative effects in several human cancer cell lines. Cancer is a leading cause of death...

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Published inMarine drugs Vol. 18; no. 5; p. 257
Main Authors Saide, Assunta, Lauritano, Chiara, Ianora, Adrianna
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 14.05.2020
MDPI AG
Subjects
anticancer compound
Antineoplastic Agents - pharmacology
cell death
Cell Line, Tumor - drug effects
chlorophyll
Chlorophyll - analogs & derivatives
Chlorophyll - chemistry
Chlorophyll - pharmacology
Humans
microalgae
pheophorbide a
Review
anticancer compound
chlorophyll
microalgae
cell death
pheophorbide a
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Summary:Chlorophyll breakdown products are usually studied for their antioxidant and anti-inflammatory activities. The chlorophyll derivative Pheophorbide (PPB ) is a photosensitizer that can induce significant anti-proliferative effects in several human cancer cell lines. Cancer is a leading cause of death worldwide, accounting for about 9.6 million deaths, in 2018 alone. Hence, it is crucial to monitor emergent compounds that show significant anticancer activity and advance them into clinical trials. In this review, we analyze the anticancer activity of PPB with or without photodynamic therapy and also conjugated with or without other chemotherapic drugs, highlighting the capacity of PPB to overcome multidrug resistance We also report other activities of PPB and different pathways that it can activate, showing its possible applications for the treatment of human pathologies.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1660-3397
1660-3397
DOI:10.3390/md18050257