PD-1 induction through TCR activation is partially regulated by endogenous TGF-β

• Published in: Cellular & molecular immunology Vol. 12; no. 5; pp. 648 - 649
• Main Authors: Rekik, Raja, Belhadj Hmida, Nadia, Ben Hmid, Ahlem, Zamali, Imen, Kammoun, Ns, Ben Ahmed, Melika
• Format: Journal Article
• Language: English
• Published: China Nature Publishing Group 01.09.2015; Nature Publishing Group/Chinese Society of Immunology
• Subjects: Humans; Leukocytes, Mononuclear - metabolism; Life Sciences; PD-1 protein; Programmed Cell Death 1 Receptor - metabolism; Receptors, Antigen, T-Cell - immunology; Receptors, Antigen, T-Cell - metabolism; Short Communication; T cell receptors; TCR; TGF-β; Transforming Growth Factor beta - metabolism; T细胞受体; T细胞增殖; 内源性; 活化; 细胞因子; 诱导
• ISSN: 1672-7681; 2042-0226
• DOI: 10.1038/cmi.2014.104

The programmed death 1 （PD-1） pathway is a way of inhibiting T-cell proliferation and cytokine production. This pathway is important for maintaining peripheral tolerance. Different mechanisms and cytokines are involved in this pathway. Herein, we show the contribution of endogenous TGF-β to increasing PD-1 expression after T cell receptor （TCR） activation.