Oxidative Stress and Hypertensive Diseases

It has become clear that reactive oxygen species (ROS) contribute to the development of hypertension via myriad effects. ROS are essential for normal cell function; however, they mediate pathologic changes in the brain, the kidney, and blood vessels that contribute to the genesis of chronic hyperten...

Full description

Saved in:
Bibliographic Details
Published inThe Medical clinics of North America Vol. 101; no. 1; p. 169
Main Authors Loperena, Roxana, Harrison, David G
Format Journal Article
LanguageEnglish
Published United States 01.01.2017
Subjects
Antioxidants - therapeutic use
Biopterins - analogs & derivatives
Biopterins - metabolism
Blood Vessels - physiopathology
Central Nervous System - physiopathology
Humans
Hypertension - physiopathology
Inflammation - physiopathology
Kidney - physiopathology
Mitochondria - metabolism
NADPH Oxidases - metabolism
Nitric Oxide Synthase - metabolism
Oxidative Stress
Reactive Oxygen Species - metabolism
Xanthine Oxidase - metabolism
Hydrogen peroxide
Dendritic cells
Renal
NADPH oxidase
Sympathetic nerves
Superoxide
Vascular
Online AccessGet more information

Cover

More Information
Summary:It has become clear that reactive oxygen species (ROS) contribute to the development of hypertension via myriad effects. ROS are essential for normal cell function; however, they mediate pathologic changes in the brain, the kidney, and blood vessels that contribute to the genesis of chronic hypertension. There is also emerging evidence that ROS contribute to immune activation in hypertension. This article discusses these events and how they coordinate to contribute to hypertension and its consequent end-organ damage.
ISSN:1557-9859
DOI:10.1016/j.mcna.2016.08.004