Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN

• Published in: Cancer letters Vol. 308; no. 1; pp. 71 - 80
• Main Authors: Heo, Ji Young, Kim, Hyun Jung, Kim, Sung-Moo, Park, Kyung-Ran, Park, Sang-Yoon, Kim, Seong Won, Nam, Dongwoo, Jang, Hyeung-Jin, Lee, Seok-Geun, Ahn, Kyoo Seok, Kim, Sung-Hoon, Shim, Bum Sang, Choi, Seung-Hoon, Ahn, Kwang Seok
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.09.2011; Elsevier Limited
• Subjects: Angiogenesis; Apoptosis; Apoptosis - drug effects; Benzoquinones - pharmacology; Caspase 3 - metabolism; Cell cycle; Cell Cycle - drug effects; Cell Growth Processes - drug effects; Cell Line, Tumor; Chemotherapy; Deoxyribonucleic acid; DNA; DNA, Neoplasm - metabolism; Down-Regulation - drug effects; Embelin; Enzyme Activation - drug effects; Enzyme Inhibitors - pharmacology; Genes; Hematology, Oncology and Palliative Medicine; Humans; Janus Kinase 2 - antagonists & inhibitors; Janus Kinase 2 - metabolism; Kinases; Male; Multiple Myeloma - drug therapy; Multiple Myeloma - genetics; Multiple Myeloma - metabolism; Multiple Myeloma - pathology; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; Phosphorylation; Phosphorylation - drug effects; Poly(ADP-ribose) Polymerases - metabolism; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - pathology; Protein Tyrosine Phosphatases - biosynthesis; Protein Tyrosine Phosphatases - genetics; Protein Tyrosine Phosphatases - metabolism; Proteins; PTEN; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Rodents; Signal Transduction - drug effects; STAT3; STAT3 Transcription Factor - antagonists & inhibitors; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Transfection; Tumors; Tyrphostins - pharmacology; Vascular endothelial growth factor; PTEN; Embelin; STAT3; Apoptosis
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2011.04.015

Highlights ► STAT3 plays an important role in carcinogenesis and metastasis of various human cancers. ► Embelin could suppress constitutive STAT3 activation through induction of PTEN. ► Embelin down-regulated the expression of STAT3-regulated gene products.