Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN
Highlights ► STAT3 plays an important role in carcinogenesis and metastasis of various human cancers. ► Embelin could suppress constitutive STAT3 activation through induction of PTEN. ► Embelin down-regulated the expression of STAT3-regulated gene products.
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Published in | Cancer letters Vol. 308; no. 1; pp. 71 - 80 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier Ireland Ltd
01.09.2011
Elsevier Limited |
Subjects | |
Online Access | Get full text |
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Summary: | Highlights ► STAT3 plays an important role in carcinogenesis and metastasis of various human cancers. ► Embelin could suppress constitutive STAT3 activation through induction of PTEN. ► Embelin down-regulated the expression of STAT3-regulated gene products. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0304-3835 1872-7980 |
DOI: | 10.1016/j.canlet.2011.04.015 |