There and back again: coordinated transcription, translation and transport in axonal survival and regeneration
Highlights • Cues in the axonal microenvironment induce local and global changes in neurons. • Bidirectional transport enables coordination of local and global changes. • Some transcription factors are translated in the axon and transported to the soma. • mRNAs are transported to and locally transla...
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Published in | Current opinion in neurobiology Vol. 39; pp. 62 - 68 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.08.2016
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Subjects | |
Online Access | Get full text |
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Summary: | Highlights • Cues in the axonal microenvironment induce local and global changes in neurons. • Bidirectional transport enables coordination of local and global changes. • Some transcription factors are translated in the axon and transported to the soma. • mRNAs are transported to and locally translated at axons for survival and growth. • Individual RBPs coordinate multiple steps of mRNA transport and regulation. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0959-4388 1873-6882 |
DOI: | 10.1016/j.conb.2016.04.006 |