There and back again: coordinated transcription, translation and transport in axonal survival and regeneration

Highlights • Cues in the axonal microenvironment induce local and global changes in neurons. • Bidirectional transport enables coordination of local and global changes. • Some transcription factors are translated in the axon and transported to the soma. • mRNAs are transported to and locally transla...

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Bibliographic Details
Published inCurrent opinion in neurobiology Vol. 39; pp. 62 - 68
Main Authors Tasdemir-Yilmaz, Ozge E, Segal, Rosalind A
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2016
Subjects
Axonal Transport - physiology
Axons - physiology
Dendrites - physiology
Nerve Regeneration
Neurology
Neurons - cytology
Neurons - physiology
Psychiatry
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Summary:Highlights • Cues in the axonal microenvironment induce local and global changes in neurons. • Bidirectional transport enables coordination of local and global changes. • Some transcription factors are translated in the axon and transported to the soma. • mRNAs are transported to and locally translated at axons for survival and growth. • Individual RBPs coordinate multiple steps of mRNA transport and regulation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2016.04.006