Growth Inhibition of Human Breast and Prostate Cancer Cells by Cinnamic Acid Derivatives and Their Mechanism of Action

Cancer is the leading cause of death and there is a particularly pressing need to develop effective treatments for breast and prostate cancer. In the current study, we show the inhibitory effects of cinnamic acid derivatives, including caffeic acid phenethyl ester (CAPE, 1), on the growth of breast...

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Bibliographic Details
Published inBiological & pharmaceutical bulletin Vol. 42; no. 7; pp. 1134 - 1139
Main Authors Imai, Masahiko, Yokoe, Hiromasa, Tsubuki, Masayoshi, Takahashi, Noriko
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.07.2019
Japan Science and Technology Agency
Subjects
Acids
Antineoplastic Agents - pharmacology
Apoptosis
Breast
Breast cancer
Breast Neoplasms - drug therapy
Caffeic acid
caffeic acid phenethyl ester
Cell Proliferation - drug effects
Cinnamates - pharmacology
Cinnamic acid
Humans
Male
MCF-7 Cells
PC-3 Cells
Prostate cancer
Prostatic Neoplasms - drug therapy
apoptosis
breast cancer
cinnamic acid
prostate cancer
caffeic acid phenethyl ester
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Summary:Cancer is the leading cause of death and there is a particularly pressing need to develop effective treatments for breast and prostate cancer. In the current study, we show the inhibitory effects of cinnamic acid derivatives, including caffeic acid phenethyl ester (CAPE, 1), on the growth of breast and prostate cancer cells. Among the compounds examined, 3,4,5-trihydroxycinnamic acid decyl ester (6) showed the most potent inhibition of cancer cell growth by the induction of apoptosis. Compound 6 could be a new anti-cancer agent for use against breast and prostate cancer.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b18-01002