Tacrolimus-related polyneuropathy: Case report and review of the literature

Abstract Patients, in particular recipients of orthotopic liver transplants, receiving the immunosuppressant tacrolimus (FK-506), are at risk for developing central neurotoxic adverse events. We report the occurrence of a tacrolimus-induced peripheral neurotoxic event, i.e. pure motor axonal polyneu...

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Published inClinical neurology and neurosurgery Vol. 110; no. 3; pp. 291 - 294
Main Authors De Weerdt, Annick, Claeys, Kristl G, De Jonghe, Peter, Ysebaert, Dirk, Chapelle, Thiery, Roeyen, Geert, Jorens, Philippe G
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.03.2008
Elsevier Science
Elsevier Limited
Subjects
Adult
Biological and medical sciences
Cytokines
Diabetic neuropathy
Female
Humans
Immunoglobulins
Immunoglobulins, Intravenous - therapeutic use
Immunosuppressive Agents - adverse effects
Liver transplantation
Liver Transplantation - immunology
Magnetic Resonance Imaging
Medical sciences
Multiple Endocrine Neoplasia Type 1 - complications
Multiple Endocrine Neoplasia Type 1 - surgery
Neurology
Neurosurgery
Neurotoxicity
Pancreas Transplantation - immunology
Pancreatectomy
Polyneuropathies - chemically induced
Polyneuropathies - drug therapy
Polyneuropathy
Postoperative period
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tacrolimus
Tacrolimus - adverse effects
Toxicity
Transplants & implants
Neurotoxicity
Immunoglobulins
Tacrolimus
Polyneuropathy
Liver transplantation
Case study
Nervous system diseases
Surgery
Liver
Peripheral nerve disease
Immunosuppressive agent
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Summary:Abstract Patients, in particular recipients of orthotopic liver transplants, receiving the immunosuppressant tacrolimus (FK-506), are at risk for developing central neurotoxic adverse events. We report the occurrence of a tacrolimus-induced peripheral neurotoxic event, i.e. pure motor axonal polyneuropathy of the lower limbs in a 44-year-old woman, 9 days after combined orthotopic liver and pancreas transplantation. She was treated for 5 days with intravenous immunoglobulins. Partial recovery followed over months to years. An overview of all 11 reported FK506-associated polyneuropathies is given.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2007.10.014