Selectivity for Specific Cardiovascular Effects of Vagal Nerve Stimulation With a Multi-Contact Electrode Cuff

The cardiovascular system can be influenced by electrically stimulating the vagal nerve. Selectivity for specific cardiac fibers may be limited when stimulating at the cervical level. Our objective was to increase effectiveness and selectivity for cardiovascular effects of vagal nerve stimulation by...

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Bibliographic Details
Published inIEEE transactions on neural systems and rehabilitation engineering Vol. 21; no. 1; pp. 32 - 36
Main Authors Ordelman, Simone C. M. A., Kornet, Lilian, Cornelussen, Richard, Buschman, Hendrik P. J., Veltink, Peter H.
Format Journal Article
LanguageEnglish
Published United States IEEE 01.01.2013
Subjects
Animals
Biomedical electrodes
Blood Pressure - physiology
cardiovascular system
Cathodes
Contacts
Electric Stimulation - instrumentation
Electrical stimulation
Equipment Design
Equipment Failure Analysis
Female
Heart rate
Heart Rate - physiology
Implantable Neurostimulators
Myocardial Contraction - physiology
Rail to rail inputs
Sensitivity and Specificity
Swine
vagus nerve
Vagus Nerve - physiology
Ventricular Function - physiology
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Summary:The cardiovascular system can be influenced by electrically stimulating the vagal nerve. Selectivity for specific cardiac fibers may be limited when stimulating at the cervical level. Our objective was to increase effectiveness and selectivity for cardiovascular effects of vagal nerve stimulation by using local bipolar stimulation in one nerve cross section using a multi-contact cuff instead of less localized stimulation using a tripolar ring electrode. Both types of cuff electrodes were compared with respect to their relative effects on R-R interval (RRI), P-Q interval (PQI), left ventricular contractility (LVC), and left ventricular pressure (P LV ) in seven pigs. Stimulation using the optimal bipolar configuration on the multi-contact cuff significantly affected RRI, PQI, LVC, and P LV , whereas stimulation with the ring electrode only significantly affected RRI and PQI. The cardiovascular parameters that could be significantly influenced varied between the bipolar configurations. These novel findings may be relevant for optimizing electrode configurations for clinical cardiac applications of vagal nerve stimulation.
ISSN:1534-4320
1558-0210
DOI:10.1109/TNSRE.2012.2214058