Desmethylanhydroicaritin isolated from Sophora flavescens , shows antitumor activities in U87MG cells via inhibiting the proliferation, migration and invasion

Highlights • DMAI showed cytotoxicity on U87MG cells. • DMAI inhibited MAPK/ERK and PI3 K/Akt/mTOR pathway. • DMAI induced morphological change and inhibition of filapodia formation. • DMAI led to down-regulation of migration and invasion of U87MG cells. • DMAI has the therapeutic potential for trea...

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Bibliographic Details
Published inEnvironmental toxicology and pharmacology Vol. 43; pp. 140 - 148
Main Authors Kang, Chang-Won, Kim, Nan-Hee, Jung, Huyn Ah, Choi, Hyung-Wook, Kang, Min-Jae, Choi, Jae-Sue, Kim, Gun-Do
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.04.2016
Subjects
Antineoplastic Agents, Phytogenic - pharmacology
Cell Line, Tumor
Cell Movement - drug effects
Cell Proliferation - drug effects
Desmethylanhydroicaritin
Emergency
Flavones - pharmacology
Humans
Invasion
Matrix Metalloproteinase 2 - metabolism
Matrix Metalloproteinase 9
Migration
Mitogen-activated protein kinase
Neoplasm Invasiveness
Phosphatidylinositol 3-Kinases - metabolism
Proliferation
Proto-Oncogene Proteins c-akt - metabolism
Sophora
TOR Serine-Threonine Kinases
U87MG
cell division cycle 2
Extracellular Receptor Kinase
Desmethylanhydroicaritin
4,6-diamidino2-phenylindole dihydrochloride hydrate
Mitogen-Activated Protein Kinase
Migration
PARP
phosphate-buffered saline
PI3 K
EGFR
BSA
mammalian target of rapamycin
mTOR
Epidermal Growth Factor Receptor
glyceraldehyde-3-phosphate dehydrogenase
Cdc42
PBS
poly(ADP-ribose) polymerase
U87MG
Mitogen Activated Protein Kinase
DAPI
Proliferation
MAPK
WST-1
Invasion
Cdc2
MMP
matrix metalloproteinase
2-(4-iodophenyl)-3(40nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium
GAPDH
phosphoinositide 3-kinase
bovine serum albumin
cell division cycle 42
ERK
Mitogen-activated protein kinase
PI3K
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Summary:Highlights • DMAI showed cytotoxicity on U87MG cells. • DMAI inhibited MAPK/ERK and PI3 K/Akt/mTOR pathway. • DMAI induced morphological change and inhibition of filapodia formation. • DMAI led to down-regulation of migration and invasion of U87MG cells. • DMAI has the therapeutic potential for treating human glioblastoma.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2016.03.003