Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders
Neuroimaging technology has provided unprecedented opportunities for elucidating the anatomical correlates of major depression. The knowledge gained from imaging research and from the postmortem studies that have been guided by imaging data is catalyzing a paradigm shift in which primary mood disord...
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Published in | Current Opinion in Neurobiology Vol. 11; no. 2; pp. 240 - 249 |
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Main Author | |
Format | Book Review Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.04.2001
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Subjects | |
Online Access | Get full text |
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Summary: | Neuroimaging technology has provided unprecedented opportunities for elucidating the anatomical correlates of major depression. The knowledge gained from imaging research and from the postmortem studies that have been guided by imaging data is catalyzing a paradigm shift in which primary mood disorders are conceptualized as illnesses that involve abnormalities of brain structure, as well as of brain function. These data suggest specific hypotheses regarding the neural mechanisms underlying pathological emotional processing in mood disorders. They particularly support a role for dysfunction within the prefrontal cortical and striatal systems that normally modulate limbic and brainstem structures involved in mediating emotional behavior in the pathogenesis of depressive symptoms. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 0959-4388 1873-6882 |
DOI: | 10.1016/S0959-4388(00)00203-8 |