Early-life origins of schizotypal traits in adulthood

• Published in: British journal of psychiatry Vol. 195; no. 2; pp. 132 - 137
• Main Authors: Lahti, Jari, Räikkönen, Katri, Sovio, Ulla, Miettunen, Jouko, Hartikainen, Anna-Liisa, Pouta, Anneli, Taanila, Anja, Joukamaa, Matti, Järvelin, Marjo-Riitta, Veijola, Juha
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.08.2009; RCP
• Subjects: Adolescent; Adult; Adulthood; Aetiology; Birth Order; Birth Weight; Body Size; Cephalometry - statistics & numerical data; Cohort analysis; Cohort Studies; Disease Susceptibility; Female; Finland; Gender; Humans; Infant; Infant, Newborn; Male; Organ Size; Placenta - anatomy & histology; Pregnancy - psychology; Pregnant women; Prenatal Exposure Delayed Effects - epidemiology; Regression Analysis; Risk Factors; Schizophrenia; Schizotypal Personality Disorder - etiology; Seasons; Sex Factors; Smoking - epidemiology; Surveys and Questionnaires; Finland
• ISSN: 0007-1250; 1472-1465
• DOI: 10.1192/bjp.bp.108.054387

Although schizotypal traits, such as anhedonia and aberrant perceptions, may increase the risk for schizophrenia-spectrum disorders, little is known about early-life characteristics that predict more pronounced schizotypal traits. To examine whether birth size or several other early-life factors that have been previously linked with schizophrenia predict schizotypal traits in adulthood. Participants of the Northern Finland 1966 Birth Cohort Study (n = 4976) completed a questionnaire on positive and negative schizotypal traits at the age of 31 years. Lower placental weight, lower birth weight and smaller head circumference at 12 months predicted elevated positive schizotypal traits in women after adjusting for several confounders (P<0.02). Moreover, higher gestational age, lower childhood family socioeconomic status, undesirability of pregnancy, winter/autumn birth, higher birth order and maternal smoking during pregnancy predicted some augmented schizotypal traits in women, some in men and some in both genders. The results point to similarities in the aetiology of schitzotypal traits and schizophrenia-spectrum disorders.