Diagnostic radiography and adult acute myeloid leukaemia: an interview and medical chart review study

• Published in: British journal of cancer Vol. 104; no. 9; pp. 1482 - 1486
• Main Authors: Pogoda, J M, Nichols, P W, Ross, R K, Stram, D O, Thomas, D C, Preston-Martin, S
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.04.2011; Nature Publishing Group
• Subjects: 692/499; 692/699/67/1990/283/1897; 692/700/1421/1770; Adult; Aged; Anemia; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Bone marrow; California - epidemiology; Cancer Research; Case-Control Studies; Drug dosages; Drug Resistance; Epidemiology; Ethnicity; Female; Hematologic and hematopoietic diseases; Humans; Interviews; Leukemia; Leukemia, Myeloid, Acute - epidemiology; Leukemia, Myeloid, Acute - ethnology; Leukemia, Myeloid, Acute - etiology; Leukemia, Myeloid, Acute - pathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical Records; Medical research; Medical sciences; Middle Aged; Molecular Medicine; Oncology; Pathology; Preventive medicine; Radiation; Radiography; Radiography - adverse effects; Retrospective Studies; Risk Assessment; Risk Factors; Short Communication; Surveys and Questionnaires; Tumors; Ultrasonic imaging; California; Los Angeles County California; Los Angeles California; United States > US; ionising radiation; radiography; acute myeloid leukaemia; case-control study; diagnostic imaging; Human; Acute myelogenous leukemia; Radiodiagnosis; Exploration; Malignant hemopathy; Case control study; Medicine; Radiography; Ionizing radiation; Cancerology; Adult; Medical imagery; Diagnosis; Bibliographic review; Cancer
• ISSN: 0007-0920; 1532-1827; 1532-1827
• DOI: 10.1038/bjc.2011.114

Background: Aetiology of acute myeloid leukaemia (AML) is not well understood, perhaps because of its distinct subtypes. High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography. Methods: Subjects were 412 matched case-control pairs. Ten-year subject histories of diagnostic radiography were based on interview and medical records. Results: There was no convincing association between AML risk and ionising radiation exposure from diagnostic imaging procedures, either for AML overall or for any AML subtype. Conclusion: The association between diagnostic radiography and AML risk remains uncertain.