A New Fluorescent Probe for Hydrogen Sulfide Detection in Solution and Living Cells

Since Hydrogen Sulfide (H2S) was recognized as a gas transmitter, its detection and quantification have become a hot research topic among chemists and biologists. In this area, fluorescent probes have shown great advantages: fast and strong response, low detection limit and easy manipulation. Here w...

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Published inMolecules (Basel, Switzerland) Vol. 28; no. 17; p. 6195
Main Authors Feng, Wei, Xiao, Qicai, Wang, Lu, Yang, Yuanyong
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 23.08.2023
MDPI
Subjects
Aqueous solutions
azide-reduction
Communication
Fluorescence
fluorescent probe
H2S quantification
H2S selective detection
Hydrogen sulfide
Polyethylene glycol
Sodium
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Summary:Since Hydrogen Sulfide (H2S) was recognized as a gas transmitter, its detection and quantification have become a hot research topic among chemists and biologists. In this area, fluorescent probes have shown great advantages: fast and strong response, low detection limit and easy manipulation. Here we developed a new fluorescent probe that detected H2S selectively among various bioactive and inorganic salts. This probe was based on the core structure of fluorescein and reacted with H2S through azide-reduction. Great linearity was achieved correlating fluorescence intensity and H2S concentrations in solution. The detection of H2S in cancer cells was also achieved.
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These authors contributed equally to this work.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28176195