Association of monocyte chemoattractant protein-1 with adipocyte number, insulin resistance and liver function markers

• Published in: Journal of medical primatology Vol. 38; no. 6; pp. 418 - 424
• Main Authors: Bose, Tanushree, Alvarenga, Juan Carlos Lopez, Tejero, M. Elizabeth, Voruganti, V. Saroja, Proffitt, J. Michael, Freeland-Graves, Jeanne H., Cole, Shelley A., Comuzzie, Anthony G.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2009
• Subjects: adipocyte number; adipocyte volume; Alanine Transaminase - blood; Animals; Aspartate Aminotransferases - blood; AST and ALT; Biomarkers - blood; Chemokine CCL2 - blood; Fatty Liver - blood; Fatty Liver - etiology; Fatty Liver - pathology; Female; Inflammation - blood; Inflammation - complications; Insulin Resistance; Intra-Abdominal Fat - pathology; liver function marker; Liver Function Tests; Male; MCP-1; NAFLD; Papio hamadryas

Background  Monocyte chemoattractant protein‐1 (MCP‐1) is an inflammatory chemokine known to induce adipocyte dedifferentiation and insulin resistance. Inflammation, insulin resistance, and obesity have been implicated in the pathogenesis of non‐alcoholic fatty liver disease (NAFLD). Methods  Fastin...