Association of monocyte chemoattractant protein-1 with adipocyte number, insulin resistance and liver function markers

• Published in: Journal of medical primatology Vol. 38; no. 6; pp. 418 - 424
• Main Authors: Bose, Tanushree, Alvarenga, Juan Carlos Lopez, Tejero, M. Elizabeth, Voruganti, V. Saroja, Proffitt, J. Michael, Freeland-Graves, Jeanne H., Cole, Shelley A., Comuzzie, Anthony G.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2009
• Subjects: adipocyte number; adipocyte volume; Alanine Transaminase - blood; Animals; Aspartate Aminotransferases - blood; AST and ALT; Biomarkers - blood; Chemokine CCL2 - blood; Fatty Liver - blood; Fatty Liver - etiology; Fatty Liver - pathology; Female; Inflammation - blood; Inflammation - complications; Insulin Resistance; Intra-Abdominal Fat - pathology; liver function marker; Liver Function Tests; Male; MCP-1; NAFLD; Papio hamadryas
• ISSN: 0047-2565; 1600-0684
• DOI: 10.1111/j.1600-0684.2009.00379.x

Background  Monocyte chemoattractant protein‐1 (MCP‐1) is an inflammatory chemokine known to induce adipocyte dedifferentiation and insulin resistance. Inflammation, insulin resistance, and obesity have been implicated in the pathogenesis of non‐alcoholic fatty liver disease (NAFLD). Methods  Fasting plasma from 43 baboons were assayed for MCP‐1, insulin, glucose, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Adipocyte number and volume were measured via biopsies of omental adipose tissue. The homeostatic model assessment method (HOMA) was used to estimate systemic insulin resistance. Results  Sex and age adjusted correlations were significant for MCP‐1 with adipocyte number (r = −0.42; P = 0.01), adipocyte volume (r = 0.38; P = 0.02), HOMA (r = 0.45; P = 0.004), ALT (r = 0.46; P = 0.03) and AST (r = 0.45; P = 0.03). Conclusions  These results suggest that MCP‐1 is related with adipocyte dedifferentiation and systemic insulin resistance, thereby potentially contributing to the development of NAFLD.