Isoniazid acetylation phenotyping in Saudi Arabs

• Published in: Journal of clinical pharmacy and therapeutics Vol. 29; no. 5; pp. 443 - 447
• Main Authors: Matar, K. M., Mayet, A. Y., Ayoola, E. A., Bawazir, S. A., Al-Faleh, F. Z., Al-Wazzan, A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.10.2004; Blackwell; Hindawi Limited
• Subjects: Acetylation; acetylator; Acetyltransferases - genetics; Acetyltransferases - pharmacology; Adolescent; Adult; Aged; Antitubercular Agents - metabolism; Biological and medical sciences; Female; Gene Frequency; Humans; isoniazid; Isoniazid - metabolism; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Phenotype; Saudi Arabia; Saudi Arabs; Saudi Arabia; Antituberculous agent; Acetylation; Metabolism; Pharmacokinetics; Antibacterial agent; Isoniazid
• ISSN: 0269-4727; 1365-2710
• DOI: 10.1111/j.1365-2710.2004.00588.x

Summary Aims:  The present study is designed to investigate the acetylator status in Saudi Arabs. Methods:  Isoniazid (INH) acetylation phenotyping was studied in 136 Saudi Arabs in Riyadh, Saudi Arabia, using a single plasma sample taken 3 h post‐INH oral dose of 200 mg. Metabolic ratio (MR) of plasma acetyl‐INH (Ac‐INH) to INH was used to determine the acetylation phenotype. Results:  The MR had a bimodal distribution with an antimode of 1·0. The frequency distribution of slow acetylators (MR < 1·0) was 94·9% (n = 129). Using Hardy–Weinberg Law, the gene frequency (q) of the recessive allele determining slow acetylator phenotype was found to be 0·97. Conclusion:  INH phenotyping suggests a high frequency of slow acetylators among Saudi Arabs. There was no association between the MR of plasma Ac‐INH/INH and age or gender.