Intoxication with pyrazolones

1 About 50 severe or fatal (mostly accidental) cases of intoxication in children by pyrazolones have been reported in the German literature of the past 59 years. 2 Characteristic symptoms are impaired consciousness progressing to coma and convulsions. In addition, sudden apnoea and cardiac arrest ma...

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Bibliographic Details
Published inBritish journal of clinical pharmacology Vol. 10; no. S2; pp. 385S - 390S
Main Author Okonek, S
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.04.1980
Subjects
Aminopyrine - poisoning
Anti-Inflammatory Agents, Non-Steroidal - poisoning
Germany, West
Hemoperfusion
Humans
Pyrazoles - poisoning
Pyrazoles - urine
Germany, West
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Summary:1 About 50 severe or fatal (mostly accidental) cases of intoxication in children by pyrazolones have been reported in the German literature of the past 59 years. 2 Characteristic symptoms are impaired consciousness progressing to coma and convulsions. In addition, sudden apnoea and cardiac arrest may occur. Hepatic lesions may develop after a latent period of 12‐24 hours. 3 Haemoperfusion seems to be the only therapeutic measure which is able to reduce the total body load of all pyrazolones to a toxicologically relevant extent. Actual clinico‐ toxicological data from poisoned patients are not available as yet; however, distribution volumes, plasma half‐lives and endogenous plasma clearances as well as removal kinetics in vitro of aminophenazone (aminopyrine), propyphenazone, metamizole (dipyrone), phenylbutazone and oxyphenbutazone as point to the efficacy of haemoperfusion with amberlite XAD‐4 resin.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0306-5251
1365-2125
DOI:10.1111/j.1365-2125.1980.tb01827.x