Polymyositis and dermatomyositis: Disease spectrum and classification

Muscle inflammation and weakness are the key features of idiopathic inflammatory myopathies (IIMs). In addition IIMs are frequently associated with cutaneous and pulmonary involvement. In clinical practice the three common inflammatory myopathies we come across are polymyositis (PM), dermatomyositis...

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Published inIndian journal of dermatology Vol. 57; no. 5; pp. 366 - 370
Main Authors Raychaudhuri, Siba P, Mitra, Anupam
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.09.2012
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Apoptosis
Autoantibodies
Care and treatment
Classification
Cytotoxicity
Dermatomyositis
Diagnosis
Disease
disease spectrum
Gene expression
Lung diseases
Lymphocytes
Medical prognosis
Polymyositis
Properties
Proteins
Skin
Studies
Symposium
India
Polymyositis
dermatomyositis
classification
disease spectrum
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Summary:Muscle inflammation and weakness are the key features of idiopathic inflammatory myopathies (IIMs). In addition IIMs are frequently associated with cutaneous and pulmonary involvement. In clinical practice the three common inflammatory myopathies we come across are polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM). The Bohan and Peter criteria combine clinical, laboratory, and pathologic features to define PM and DM. They did not recognize inclusion body myositis (IBM) or other inflammatory myopathies, such as granulomatous and eosinophilic myositis. Thus the disease spectrum is wide and IIMs are a heterogeneous group of autoimmune disorders. To address these issues in this article we have discussed the currently developing newer classifications of IIMs.
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ISSN:0019-5154
1998-3611
DOI:10.4103/0019-5154.100477