Resting state functional network switching rate is differently altered in bipolar disorder and major depressive disorder

• Published in: Human brain mapping Vol. 41; no. 12; pp. 3295 - 3304
• Main Authors: Han, Shaoqiang, Cui, Qian, Wang, Xiao, Li, Liang, Li, Di, He, Zongling, Guo, Xiaonan, Fan, Yun‐Shuang, Guo, Jing, Sheng, Wei, Lu, Fengmei, Chen, Huafu
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 15.08.2020
• Subjects: Amygdala; Bipolar disorder; Configurations; Cortex (parietal); dynamic networks configuration; Flexibility; fMRI; Functional magnetic resonance imaging; Magnetic resonance imaging; Major depressive disorder; Medical research; Medicine, Experimental; Mental depression; multilayer network method; Neostriatum; Network switches; Network switching; network switching rate; Neural networks; Neuroimaging; Parahippocampal gyrus; Prefrontal cortex; Switching; fMRI; bipolar disorder; dynamic networks configuration; multilayer network method; major depressive disorder; network switching rate
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.25017

The clinical misdiagnosis ratio of bipolar disorder (BD) patients to major depressive disorder (MDD) patients is high. Recent findings hypothesize that the ability to flexibly recruit functional neural networks is differently altered in BD and MDD patients. This study aimed to explore distinct aberrance of network flexibility during dynamic networks configuration in BD and MDD patients. Resting state functional magnetic resonance imaging of 40 BD patients, 61 MDD patients, and 61 matched healthy controls were recruited. Dynamic functional connectivity matrices for each subject were constructed with a sliding window method. Then, network switching rate of each node was calculated and compared among the three groups. BD and MDD patients shared decreased network switching rate of regions including left precuneus, bilateral parahippocampal gyrus, and bilateral dorsal medial prefrontal cortex. Apart from these regions, MDD patients presented specially decreased network switching rate in the bilateral anterior insula, left amygdala, and left striatum. Taken together, BD and MDD patients shared decreased network switching rate of key hubs in default mode network and MDD patients presented specially decreased switching rate in salience network and striatum. We found shared and distinct aberrance of network flexibility which revealed altered adaptive functions during dynamic networks configuration of BD and MDD. This study explored distinct aberrance of network flexibility during dynamic networks configuration in BD and MDD patients. We found shared and distinct aberrance of network flexibility which revealed altered adaptive functions during dynamic networks configuration of BD and MDD.