Effect of Mosapride on Recovery of Intestinal Motility After Hand-Assisted Laparoscopic Colectomy for Carcinoma

• Published in: Diseases of the colon & rectum Vol. 51; no. 11; pp. 1692 - 1695
• Main Authors: Narita, Kazuhiro, Tsunoda, Akira, Takenaka, Koji, Watanabe, Makoto, Nakao, Kentaro, Kusano, Mitsuo
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.11.2008; The ASCRS; Lippincott Williams & Wilkins; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Adult; Aged; Aged, 80 and over; Benzamides - therapeutic use; Biological and medical sciences; Carcinoma - physiopathology; Carcinoma - therapy; Colectomy - adverse effects; Colonic Neoplasms - physiopathology; Colonic Neoplasms - therapy; Colorectal Surgery; Digestive system. Abdomen; Endoscopy; Female; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal Motility - physiology; Humans; Ileus - etiology; Ileus - prevention & control; Investigative techniques, diagnostic techniques (general aspects); Laparoscopy - adverse effects; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Morpholines - therapeutic use; Oncology; Original Contribution; Recovery of Function; Serotonin Receptor Agonists - therapeutic use; Single-Blind Method; Stomach, duodenum, intestine, rectum, anus; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Surgical Oncology; Gastric emptying; C]-acetate breath test; Postoperative ileus; [; Mosapride citrate; Agonist; 5-HT4 Serotonine receptor; Carcinoma; Motility; Citrate; Colectomy; Prokinetic agent; Recovery; Mosapride; Surgery; Gastroenterology; Endoscopy; Colon; Gut; Laparoscopy; Malignant tumor; Hand; [13C]-acetate breath test; Breath test; Treatment; Benzamide derivatives; Cancer
• ISSN: 0012-3706; 1530-0358
• DOI: 10.1007/s10350-008-9407-0

Purpose Mosapride citrate (mosapride) is a serotonin 5-hydroxytryptamine 4 receptor agonist known to promote gastric emptying and large-intestine motility. We assessed the effect of mosapride on postoperative ileus following colon surgery. Methods Forty patients with colon cancer undergoing hand-assisted laparoscopic colectomy were randomly assigned to a mosapride group or a control group. The mosapride group received 15 mg of mosapride by mouth with 50 ml of water three times a day, starting on postoperative day 1. The control group received 50 ml of water on the same schedule. Patients were allowed to resume oral feeding on the evening of postoperative day 2. Postoperative time to first bowel movement was evaluated by one investigator blinded to treatment. Postoperative gastric emptying was evaluated with the [ 13 C]-acetate breath test at 24 and 48 hours after the operation. Results Postoperative time to first bowel movement was significantly shorter in the mosapride group than in the control group (48.5 vs. 69.3 hours, P  = 0.0149). The time to maximal gastric emptying rate as determined by the breath test was significantly shorter in the mosapride group than in the control group at the 48-hour time point (27.9 vs. 35.3 minutes, P  = 0.0294). Postoperative hospital stay was shorter in patients receiving mosapride than in controls (6.7 vs. 8.4 days, P  = 0.0398). No adverse effects were observed with mosapride. Conclusions Gastric emptying was improved by mosapride. The results suggested that the period of postoperative ileus following hand-assisted laparoscopic colectomy can be shortened by treatment with mosapride.